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Fig. 5 | BMC Veterinary Research

Fig. 5

From: Systemic immune response and virus persistence after foot-and-mouth disease virus infection of naïve cattle and cattle vaccinated with a homologous adenovirus-vectored vaccine

Fig. 5

CD4+ and CD8+ αβ T cells in vaccinated and non-vaccinated animals. Panels a and b show percentage values relative to the CD3+ αβ T cell parent population, and panels C and D show absolute cell counts per μL of blood obtained by a dual-platform method. Group means (CD4+: diamonds, CD8+: triangles) are annotated with their 95 % confidence intervals, non-vaccinated animals are shown in red and vaccinated animals in blue. Based on relative percentage-of-parent values, there was a significant increase of CD4+ αβ T cells (panel a) and a corresponding decrease of CD8+ αβ T cells (b) in non-vaccinated animals. Translated to absolute counts, the increase in total circulating lymphocytes of up to 25 % in vaccinated animals had greater influence than the relative differences between vaccinated and non-vaccinated animals. Thus, absolute quantities of both CD4+ (c) as well as CD8+ αβ T cells (d) were significantly higher in PBMCs of vaccinated steers than in non-vaccinated steers

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BMC Veterinary Research

ISSN: 1746-6148

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