Table 6 Selected kidney, liver and hematological variables at study exit
Variable (Laboratory reference range) | Robenacoxib (n = 170) | Placebo (n = 172) | P value | ||||
|---|---|---|---|---|---|---|---|
Mean (SD) | N a | Mean (SD) | N a | ||||
Higher | Lower | Higher | Lower | ||||
Serum | |||||||
Urea nitrogen, mg/dL (14–36 mg/dL) | 23.5 (6.58) | 6 | 2 | 22.1 (5.82) | 3 | 2 | 0.21 |
Creatinine, mg/dL (0.6–2.4 mg/dL) | 0.88 (0.19) | 0 | 2 | 0.94 (0.32) | 1 | 6 | 0.093 |
Alkaline phosphatase, U/L (6–102 U/L) | 48.5 (25.8) | 5 | 0 | 52.5 (31.3) | 14 | 0 | 0.10 |
Alanine aminotransferase, U/L (10–100 U/L) | 52.1 (19.1) | 5 | 4 | 58.6 (44.7) | 8 | 3 | 0.26 |
Aspartate aminotransferase, U/L (10–100 U/L) | 32.7 (21.7) | 3 | 0 | 31.3 (18.1) | 3 | 0 | 0.59 |
Total bilirubin, mg/dL (0.1–0.4 mg/dL) | 0.11 (0.031) | 0 | 0 | 0.11 (0.043) | 1 | 0 | 0.54 |
Total protein, g/dL (5.2–8.8 g/dL) | 6.91 (0.63) | 1 | 0 | 6.95 (0.55) | 0 | 0 | 0.34 |
Albumin, g/dL (2.5–3.9 g/dL) | 3.44 (0.36) | 11 | 1 | 3.44 (0.34) | 8 | 1 | 0.47 |
Hematology | |||||||
Hemoglobin, g/dL (9.3–15.9 g/dL) | 12.1 (1.57) | 1 | 5 | 11.9 (1.74) | 0 | 10 | 0.49 |
Hematocrit, % (29–48 %) | 37.0 (5.19) | 6 | 8 | 36.4 (5.57) | 1 | 18 | 0.39 |
Platelet count, 103/μL (200–500 103/μL) | 275.4 (105.0) | 5 | 39 | 290.8 (109.5) | 6 | 31 | 0.51 |
Urineb | |||||||
Urine specific gravity (1.015–1.060) | 1.067 (0.018) | 109 | 0 | 1.058 (0.019) | 79 | 6 | 0.014 |