|
Cephalosporin
|
(Animal) species
|
Reported body weight (kg)
|
Extrapolated volume of distribution (L/kg)
|
Extrapolated clearance (L/kg/h)
|
Observed volume of distribution (L/kg)
|
Observed clearance (L/kg/h)
|
Reference
|
|---|
|
Ceftriaxone
|
Human
|
72
|
0.40
|
0.28
|
0.11 ± 0.02
|
0.012 a
|
Paradis [34]
|
| |
Human
|
79
|
0.39
|
0.28
|
0.12 ± 0.02
|
0.011 c
|
Chiu [50]
|
|
Ceftazidime
|
Human
|
72.0
|
0.35
|
0.15
|
0.21 ± 0.03
|
0.095 ± 0.014 a
|
Paradis [34]
|
| |
Human
|
70.8
|
0.35
|
0.15
|
0.204 ± 0.02
|
0.069 ± 0.011e
|
Paulfeuerborn [35]
|
|
Cefepime
|
Human
|
70
|
0.21
|
0.09
|
0.23
|
0.092 b
|
Bacher [51]
|
| |
Human
|
74
|
0.21
|
0.09
|
0.25
|
0.101 b
|
Barbhaiya [52]
|
|
Ceftiofur
|
Goat (non-lactating)
|
58.5
|
0.53
|
0.06
|
0.25
|
0.067 a
|
Courtin [53]
|
| |
Camel
|
400
|
0.97
|
0.09
|
0.13 ± 0.03
|
0.03 ± 0.001
|
Goudah [54]
|
| |
Asian elephant
|
3530
|
1.91
|
0.15
|
0.51 ± 0.29
|
0.069 ± 0.043
|
Dumonceaux [55]
|
|
Cefquinome
|
Duck
|
2.2
|
0.25
|
0.27
|
0.41 ± 0.04
|
0.22 ± 0.02
|
Yuan [56]
|
| |
Buffalo
|
123
|
0.21
|
0.15
|
0.26 ± 0.006
|
0.061 d
|
Dinakaran [57]
|
- Data are observed values from pharmacokinetic studies after intravenous administration of cephalosporin to healthy subjects. Values are reported as value ± SD where possible
-
a Recalculated from ml/kg/min. b Recalculated from ml/min. c Recalculated from L/h. d Recalculated from ml/kg/h. e Recalculated from ml/min/1.73 m2 (assuming 1.73 m2 equals a 70 kg weighing human)
