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Table 2 Extrapolated volume of distribution and clearance by allometric scaling versus volume of distribution and clearance

From: Modelling concentrations of antimicrobial drugs: comparative pharmacokinetics of cephalosporin antimicrobials and accuracy of allometric scaling in food-producing and companion animals

Cephalosporin (Animal) species Reported body weight (kg) Extrapolated volume of distribution (L/kg) Extrapolated clearance (L/kg/h) Observed volume of distribution (L/kg) Observed clearance (L/kg/h) Reference
Ceftriaxone Human 72 0.40 0.28 0.11 ± 0.02 0.012 a Paradis [34]
  Human 79 0.39 0.28 0.12 ± 0.02 0.011 c Chiu [50]
Ceftazidime Human 72.0 0.35 0.15 0.21 ± 0.03 0.095 ± 0.014 a Paradis [34]
  Human 70.8 0.35 0.15 0.204 ± 0.02 0.069 ± 0.011e Paulfeuerborn [35]
Cefepime Human 70 0.21 0.09 0.23 0.092 b Bacher [51]
  Human 74 0.21 0.09 0.25 0.101 b Barbhaiya [52]
Ceftiofur Goat (non-lactating) 58.5 0.53 0.06 0.25 0.067 a Courtin [53]
  Camel 400 0.97 0.09 0.13 ± 0.03 0.03 ± 0.001 Goudah [54]
  Asian elephant 3530 1.91 0.15 0.51 ± 0.29 0.069 ± 0.043 Dumonceaux [55]
Cefquinome Duck 2.2 0.25 0.27 0.41 ± 0.04 0.22 ± 0.02 Yuan [56]
  Buffalo 123 0.21 0.15 0.26 ± 0.006 0.061 d Dinakaran [57]
  1. Data are observed values from pharmacokinetic studies after intravenous administration of cephalosporin to healthy subjects. Values are reported as value ± SD where possible
  2. a Recalculated from ml/kg/min. b Recalculated from ml/min. c Recalculated from L/h. d Recalculated from ml/kg/h. e Recalculated from ml/min/1.73 m2 (assuming 1.73 m2 equals a 70 kg weighing human)