Serum concentration of ketamine and antinociceptive effects of ketamine and ketamine-lidocaine infusions in conscious dogs

Table 4 Sedation score in median (IQR) values across each time points of the each group after administration of K30, K50, and KL30 in 6 dogs

Time (minutes)	K30	KL30	K50^a
0	0 (0–0)	0 (0–0)	0 (0–0)
01	0 (0–0)	0 (0–0)	3 (0–3)
05	0 (0–0)	0 (0–0)	3 (0–3)
20	0 (0–0)	0 (0–0)	3 (0–3)
40	0 (0–0)	0 (0–0)	1 (0–3)
60	0 (0–0)	0 (0–0)	1 (0–3)
90	0 (0–0)	0 (0–0)	1 (0–3)
120	0 (0–0)	0 (0–0)	0 (0–0)
140	0 (0–0)	0 (0–0)	0 (0–0)
160	0 (0–0)	0 (0–0)	0 (0–0)

K30 ketamine 0.5 mg/kg loading dose followed by 30 μg/kg/min, K50 0.5 mg/kg loading dose followed by 50 μg/kg/min, KL = ketamine 0.5 loading dose followed by 30 μg/kg/min + lidocaine 2 mg/kg loading dose followed by 100 μg/kg/min. Overall significance was set at a value of P < 0.05. ^aK50 is significantly different from K30 and KL at P < 0.003 (Friedman test)

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