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Table 7 Cytotoxic features of QdNOs and their main metabolites in PK-15, Marc-145 and DF-1 cells

From: In vitro antimicrobial activities of animal-used quinoxaline 1,4-di-N-oxides against mycobacteria, mycoplasma and fungi

     

(Unit: μg/mL, mean ± SD, n = 4)

Drugs

PK-15

Marc-145

DF-1

TC50

MNTC

TC50

MNTC

TC50

MNTC

CYA

15.31 ± 1.23

1.2

16.92 ± 1.28

1.56

17.26 ± 1.27

1.0

Cy1

23.40 ± 2.14

2.0

37.83 ± 1.67

3.9

32.97 ± 2.35

2.0

Cy2

51.73 ± 2.96

2.0

96.55 ± 3.12

2.0

35.48 ± 2.87

1.0

Cy10

25.27 ± 1.55

2.0

33.62 ± 1.85

2.0

49.2 ± 1.93

2.0

QCT

2.38 ± 0.27

0.2

8.90 ± 1.05

0.39

9.89 ± 1.08

0.25

Q2

0.81 ± 0.12

0.1

3.76 ± 0.59

0.2

1.86 ± 0.24

0.06

MEQ

17.86 ± 1.28

0.5

41.28 ± 1.28

1.0

40.01 ± 1.27

2.0

M1

72.90 ± 2.66

2.0

70.77 ± 1.57

1.0

54.8 ± 1.93

1.0

M4

40.81 ± 1.27

3.9

128.62 ± 2.67

3.9

37.75 ± 2.68

1.0

M5

40.41 ± 3.21

2.0

89.66 ± 2.14

2.0

38.2 ± 2.09

2.0

M6

78.82 ± 3.57

2.0

89.82 ± 1.57

2.0

41.26 ± 1.27

2.0

Ribavirin

44.80 ± 1.58

2.0

75.49 ± 2.54

8.6

67.42 ± 2.58

4.0