Table 6 In vitro activity of cyadox, quinocetone and mequindox in combination with various antibacterials against Mycobacterium tuberculosis complex
Drug combination | M. bovis ATCC 19210 | M. tb H37Rv ATCC 27294 | ||||
|---|---|---|---|---|---|---|
FICA + FICB | FIC | Combined effect | FICA + FICB | FIC | Combined effect | |
CYA + Rifampicin | 0.5 + 0.25 | 0.75 | additive | 0.5 + 0.25 | 0.75 | additive |
CYA + Isoniazide | 1 + 0.5 | 1.5 | indifferent | 1 + 0.25 | 1.25 | indifferent |
CYA + Streptomycin | 0.5 + 0.25 | 0.75 | additive | 0.5 + 0.5 | 1 | additive |
CYA + Kanamycin | 1 + 0.5 | 1.25 | indifferent | 1 + 0.5 | 1.5 | indifferent |
CYA + Ethambutol | 1 + 0.5 | 1.5 | indifferent | 1 + 0.25 | 1.25 | indifferent |
CYA + Amikacin | 1 + 0.5 | 1.5 | indifferent | 1 + 0.25 | 1.25 | indifferent |
QCT + Rifampicin | 0.5 + 0.5 | 1 | additive | 0.5 + 0.25 | 0.75 | additive |
QCT + Isoniazide | 1 + 0.5 | 1.5 | indifferent | 1 + 0.25 | 1.25 | indifferent |
QCT + Streptomycin | 0.5 + 0.5 | 1 | additive | 1 + 0.25 | 1.25 | indifferent |
QCT + Kanamycin | 1 + 0.5 | 1.25 | indifferent | 1 + 0.5 | 1.5 | additive |
QCT + Ethambutol | 1 + 0.5 | 1.5 | indifferent | 1 + 0.25 | 1.25 | indifferent |
QCT + Amikacin | 0.5 + 0.5 | 1 | additive | 1 + 0.5 | 1.5 | indifferent |
MEQ + Rifampicin | 0.5 + 0.5 | 1 | additive | 0.5 + 0.25 | 0.75 | additive |
MEQ + Isoniazide | 1 + 0.5 | 1.5 | indifferent | 1 + 0.25 | 1.25 | indifferent |
MEQ + Streptomycin | 1 + 0.5 | 1.55 | additive | 1 + 0.5 | 1.5 | additive |
MEQ + Kanamycin | 1 + 0.5 | 1.5 | indifferent | 0.5 + 0.5 | 1 | additive |
MEQ + Ethambutol | 1 + 0.5 | 1.5 | indifferent | 1 + 0.5 | 1.5 | indifferent |
MEQ + Amikacin | 1 + 0.5 | 1.55 | indifferent | 1 + 0.5 | 1.5 | indifferent |