Skip to main content

Table 1 Haematological parameters of Case 1 and Case 2 measured during clinical EEHV-1A infection

From: Surviving and fatal Elephant Endotheliotropic Herpesvirus-1A infections in juvenile Asian elephants – lessons learned and recommendations on anti-herpesviral therapy

A
Days WBC (*10e9/L) Neutrophils (*10e9/L) Lymphocytes (*10e9/L) Monocytes (*10e9/L) Eosinophils (*10e9/L) Basophils (*10e9/L)    
7 22.85 7.77 8.91 5.94 (26 %) 0.23 0    
23 13.69 5.75 2.87 6.16 (45 %) 0 0    
213 15.91 4.61 5.73 5.25 (33 %) 0.32 0    
Physiological mean
(% of WBC)
15.51 3.77 (25.5 %) 5.02
(23.65 %)
6.46
(50 %)
0.24
(1.55 %)
0.02
(0.10 %)
   
Days RBC (*10e12/L) HGB (g/dL) HCT (%) MCV (fL) MCH (pg) MCHV (g/dL) RDW
(%)
PLT (*10e9/L) PCV (%)
7 3.54 13.4 37.7 107 37.8 35.5 14.3 470 36
23 5.06 19.2 55.1 109 37.9 34.8 14.5 968 55
213 3.62 13.3 39.2 108 36.8 33.9 13.9 996 37
Physiological (mean) 3.55 14.28 40.60 114.25 40.19 35.17 14.33 617.65 40.80
B
Days EEHV-1A
(vgc/ml)
WBC
(*10e9/L)
Neutrophils (*10e9/L) Lymphocytes (*10e9/L) Monocytes (*10e9/L) Eosinophils (*10e9/L) Basophils (*10e9/L)   
-33 5.0 × 102 23.08 4.62 5.77 12.46 (54 %) 0 0   
-29 ND 25.34 4.56 7.6 13.18 (52) % 0 0   
-5 1.2 × 105 6.18 3.46 1.85 0.8 (13 %) 0.06 0   
-3 2.7 × 106 7.35 5.22 1.32 0.81 (11 %) 0 0   
0 7.2 × 106 13.25 8.22 2.65 2.25 (17 %) 0.13 0   
1 1.9 × 107 12.925 7.565 2 2.975 (23 %) 0 0.195   
Physiological mean (% of WBC)   15.51 3.77 (25.5 %) 5.02 (23.65 %) 6.46 (50 %) 0.24 (1.55 %) 0.02 (0.10 %)   
Days RBC (*10e12/L) HGB (g/dL) HCT (%) MCV (fL) MCH (pg) MCHV (g/dL) RDW (%) PLT (*10e9/L) PCV
(%)
-33 3.65 14.6 43.2 118.3 39.9 33.7 13.9 950 42
-29 3.58 14.5 41.4 115.5 40.4 35 38.1 760 38
-5 3.48 14.2 41.8 120.4 41 34 14 560 37
-3 3.36 14.2 38.4 114.4 42.4 37.1 13.7 183 38
0 2.89 12.4 32.9 113.7 42.9 37.8 13.8 98 34
1 3.07 12.95 35.05 114.2 42.2 36.9 13.6 13 36.5
Physiological mean 3.55 14.28 40.60 114.25 40.19 35.17 14.33 617.65 40.80
  1. The haematological parameters for Case 1 (A) were only available for Days 7, 23 and 213 following suspicion of clinical EEHV-1A infection. The haematological parameters and viral load for Case 2 (B) were measured on several occasions from 33 days prior to the observation of signs indicative of clinical EEHV-1A infection (Day 0) to the Day 1 when the elephant succumbed to the infection at midnight. Normal platelet range of live juveniles in the collection was established, during a period of seven months from 20 blood samples of the elephants, to be at 372-878*10e9/L (mean of 625*10e9/L). The rest of the physiological parameters were from 24 measurements from four individuals under eight years of age (age range at time of sampling: 1.5-7y). Parameter values with a substantial change are highlighted in bold. Percentages of monocytes in the white blood cells are also given in the table
  2. vgc/ml, viral genome copies per millilitre of EDTA whole blood; WBC, white blood cell count; RBC, red blood cell count; HGB, haemoglobin; HCT, haematocrit; MCV, mean cell volume; MCH, mean corpuscular haemoglobin; MCHV, mean corpuscular haemoglobin volume; RDW, red blood cell distribution width; PLT, platelet count; PCV, packed cell volume; ND, not detected