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Fig. 3 | BMC Veterinary Research

Fig. 3

From: Surviving and fatal Elephant Endotheliotropic Herpesvirus-1A infections in juvenile Asian elephants – lessons learned and recommendations on anti-herpesviral therapy

Fig. 3

Penciclovir, the metabolite of famciclovir, plasma levels in 2 juvenile Asian elephants with EEHV-1A DNAemia. Famciclovir (FCV) was rectally administered in Case 1 at 15 mg/kg twice daily (BID) on observation of clinical signs indicative of EEHV-1A infection (Day 0) and continued at the same dose rate until Day 1, when it was reduced to 12 mg/kg thrice daily (TID). This was followed by further reduction on Day 3 to 8 mg/kg BID and continued unchanged until Day 18. In Case 2 FCV was administered at 15 mg/kg TID for two days following the detection of EEHV-1A DNA in the blood (Day -5), five days prior to observation of EEHV-1A clinical signs, and continued at the same dosage till the last dose of FCV at 9:00 am on Day 0; blood was only collected at 17:00 pm on that day. The death of Case 2 was at midnight on Day 1; seven days after first detection of EEHV-1 DNA in the blood. Dashed line indicates the minimum level of PCV considered therapeutic in humans with genital herpes (>100 ng/ml) [27]

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