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Table 1 Oral bioavailability (F) compared to transfer ratio’s (TR) of chlortetracycline (CTC), doxycycline (DOX) and sulfadiazine (SDZ)

From: Residues of chlortetracycline, doxycycline and sulfadiazine-trimethoprim in intestinal content and feces of pigs due to cross-contamination of feed

Antimicrobial

F

TR

CM

PCA

DCA

CD

Feces

CTC

6 % [25]

69.6 %

84.2 %

71.4 %

101.0 %

102.5 %

DOX

21–50 % [24, 26]

24.3 %

45.1 %

36.6 %

51.9 %

55.4 %

SDZ

85–100 % [22, 23]

3.7 %

3.5 %

5.2 %

4.2 %

4.7 %

  1. TR’s are calculated by dividing the mean concentration (6 pigs) in the content of an intestinal segment (CM caecum, PCA proximal colon ascendens, DCA distal colon ascendens, CD colon descendens) after 10 days of feeding by the mean concentration in the feed. The mean concentration in the feces was taken over day 4 - day 10 (steady-state)