Fig. 2

Alignment of ARSB DNA sequence fragments across mammals. Presented are the wildtype sequences for the domestic cat and other species and the cat sequences with variants at the nucleotide indicated with a box. The mutation sites are the L476P (CTC to CCC) and the D520N mutation (GAC to AAC). Note each mutation is on the wildtype sequence background and not compound heterozygotes. Both sites are conserved across mammals. Alignment produced by ClustalX software. The asterisks indicate conservation of the wildtype nucleotide across all species