TY - JOUR AU - Wambacq, Wendy AU - Rybachuk, Galena AU - Jeusette, Isabelle AU - Rochus, Kristel AU - Wuyts, Brigitte AU - Fievez, Veerle AU - Nguyen, Patrick AU - Hesta, Myriam PY - 2016 DA - 2016/06/28 TI - Fermentable soluble fibres spare amino acids in healthy dogs fed a low-protein diet JO - BMC Veterinary Research SP - 130 VL - 12 IS - 1 AB - Research in cats has shown that increased fermentation-derived propionic acid and its metabolites can be used as alternative substrates for gluconeogenesis, thus sparing amino acids for other purposes. This amino acid sparing effect could be of particular interest in patients with kidney or liver disease, where this could reduce the kidneys’/liver’s burden of N-waste removal. Since dogs are known to have a different metabolism than the obligatory carnivorous cat, the main objective of this study was to assess the possibility of altering amino acid metabolism through intestinal fermentation in healthy dogs. This was studied by supplementing a low-protein diet with fermentable fibres, hereby providing an initial model for future studies in dogs suffering from renal/liver disease. SN - 1746-6148 UR - https://doi.org/10.1186/s12917-016-0752-2 DO - 10.1186/s12917-016-0752-2 ID - Wambacq2016 ER -