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Table 4 Biochemical parameters in rats intragastrically administered different drugs (n = 10)

From: Evaluation on antithrombotic effect of aspirin eugenol ester from the view of platelet aggregation, hemorheology, TXB2/6-keto-PGF1α and blood biochemistry in rat model

Variables

Unit

Control

Model

CMC-Na

Aspirin

Eugenol

AEE L

AEE M

AEE H

Combination

T-BIL

umol/L

0.90 ± 0.13

0.97 ± 0.19

1.00 ± 0.17

0.74 ± 0.12**

1.11 ± 0.17

0.72 ± 0.15**

0.65 ± 0.10**

0.86 ± 0.12

1.17 ± 0.17*

TP

g/L

58 ± 2.9##

53 ± 4.3

50 ± 3.4

60 ± 2.2**

50 ± 4.7

59 ± 2.4**

60 ± 3.3**

58 ± 4.1**

61 ± 3.9**

ALB

g/L

23 ± 1.0##

20 ± 1.4

18 ± 1.1##

20 ± 0.8*

19 ± 1.4

21 ± 2.3**

21 ± 0.7**

20 ± 1.1*

22 ± 1.2**

ALT

U/L

69 ± 10##

57 ± 9

67 ± 12#

61 ± 5

68 ± 13

65 ± 6

65 ± 6

58 ± 14

67 ± 13

AST

U/L

79 ± 11#

93 ± 10

85 ± 12

65 ± 8**

96 ± 14

76 ± 10

75 ± 16

74 ± 12

120 ± 14**

ALP

U/L

240 ± 19##

145 ± 22

156 ± 22

178 ± 27

137 ± 23

180 ± 25

181 ± 21

177 ± 11

172 ± 54

GGT

U/L

3.16 ± 0.49

3.34 ± 0.44

3.20 ± 0.25

3.44 ± 0.45

3.15 ± 0.67

3.55 ± 0.57

3.72 ± 0.64

3.61 ± 0.51

3.62 ± 0.60

LDH

U/L

141 ± 28

129 ± 29

161 ± 18#

123 ± 31*

190 ± 27

128 ± 20

126 ± 22

140 ± 38

227 ± 36**

BUN

mmol/L

8.0 ± 0.6

8.9 ± 1.7

9.9 ± 1.7

11.5 ± 1.4*

10.3 ± 1.9

9.4 ± 0.7

9.7 ± 1.5

8.3 ± 0.9 *

12.5 ± 1.3**

CR

umol/L

27.3 ± 4.6

29.3 ± 4.9

29.0 ± 4.8

37.4 ± 3.6*

31.6 ± 4.1

24.9 ± 3.8

32.1 ± 4.6

26.2 ± 3.2

36.4 ± 4.7**

Glu

mmol/L

8.01 ± 0.68

8.11 ± 0.68

7.98 ± 0.53

7.78 ± 0.38

7.52 ± 0.30

7.50 ± 0.81

7.40 ± 0.25

7.57 ± 0.62

7.90 ± 0.81

Ca

mmol/L

2.42 ± 0.06##

2.08 ± 0.10

2.12 ± 0.15

2.30 ± 0.05**

2.12 ± 0.12

2.47 ± 0.12**

2.35 ± 0.05**

2.24 ± 0.14*

2.19 ± 0.06

P

mmol/L

3.31 ± 0.19

3.47 ± 0.25

3.50 ± 0.60

3.36 ± 0.40

3.64 ± 0.43

3.23 ± 0.45

3.36 ± 0.20

3.54 ± 0.15

3.53 ± 0.22

TG

mmol/L

1.19 ± 0.21##

0.66 ± 0.09

0.78 ± 0.06

0.56 ± 0.09*

0.69 ± 0.16

0.71 ± 0.19

0.59 ± 0.15

0.58 ± 0.27*

0.77 ± 0.21

TCH

mmol/L

1.37 ± 0.07##

1.98 ± 0.08

1.81 ± 0.23

1.53 ± 0.17**

1.93 ± 0.18

1.62 ± 0.12*

1.56 ± 0.18*

1.55 ± 0.26**

1.96 ± 0.29

  1. After the last measurement of thrombosis length at 48 h, blood was drawn from the heart. Serum samples were prepared by centrifugation and analyzed using an automatic biochemistry analyzer. # P < 0.05, ## P < 0.01 compared with the model group. *P < 0.05, **P < 0.01 compared with the CMC-Na group. AEE L: AEE 18 mg/kg; AEE M: 36 mg/kg; AEE H: AEE 72 mg/kg; Combination: combination of aspirin and eugenol (molar ratio 1:1)
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BMC Veterinary Research

ISSN: 1746-6148

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