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Table 4 Biochemical parameters in rats intragastrically administered different drugs (n = 10)

From: Evaluation on antithrombotic effect of aspirin eugenol ester from the view of platelet aggregation, hemorheology, TXB2/6-keto-PGF and blood biochemistry in rat model

Variables Unit Control Model CMC-Na Aspirin Eugenol AEE L AEE M AEE H Combination
T-BIL umol/L 0.90 ± 0.13 0.97 ± 0.19 1.00 ± 0.17 0.74 ± 0.12** 1.11 ± 0.17 0.72 ± 0.15** 0.65 ± 0.10** 0.86 ± 0.12 1.17 ± 0.17*
TP g/L 58 ± 2.9## 53 ± 4.3 50 ± 3.4 60 ± 2.2** 50 ± 4.7 59 ± 2.4** 60 ± 3.3** 58 ± 4.1** 61 ± 3.9**
ALB g/L 23 ± 1.0## 20 ± 1.4 18 ± 1.1## 20 ± 0.8* 19 ± 1.4 21 ± 2.3** 21 ± 0.7** 20 ± 1.1* 22 ± 1.2**
ALT U/L 69 ± 10## 57 ± 9 67 ± 12# 61 ± 5 68 ± 13 65 ± 6 65 ± 6 58 ± 14 67 ± 13
AST U/L 79 ± 11# 93 ± 10 85 ± 12 65 ± 8** 96 ± 14 76 ± 10 75 ± 16 74 ± 12 120 ± 14**
ALP U/L 240 ± 19## 145 ± 22 156 ± 22 178 ± 27 137 ± 23 180 ± 25 181 ± 21 177 ± 11 172 ± 54
GGT U/L 3.16 ± 0.49 3.34 ± 0.44 3.20 ± 0.25 3.44 ± 0.45 3.15 ± 0.67 3.55 ± 0.57 3.72 ± 0.64 3.61 ± 0.51 3.62 ± 0.60
LDH U/L 141 ± 28 129 ± 29 161 ± 18# 123 ± 31* 190 ± 27 128 ± 20 126 ± 22 140 ± 38 227 ± 36**
BUN mmol/L 8.0 ± 0.6 8.9 ± 1.7 9.9 ± 1.7 11.5 ± 1.4* 10.3 ± 1.9 9.4 ± 0.7 9.7 ± 1.5 8.3 ± 0.9 * 12.5 ± 1.3**
CR umol/L 27.3 ± 4.6 29.3 ± 4.9 29.0 ± 4.8 37.4 ± 3.6* 31.6 ± 4.1 24.9 ± 3.8 32.1 ± 4.6 26.2 ± 3.2 36.4 ± 4.7**
Glu mmol/L 8.01 ± 0.68 8.11 ± 0.68 7.98 ± 0.53 7.78 ± 0.38 7.52 ± 0.30 7.50 ± 0.81 7.40 ± 0.25 7.57 ± 0.62 7.90 ± 0.81
Ca mmol/L 2.42 ± 0.06## 2.08 ± 0.10 2.12 ± 0.15 2.30 ± 0.05** 2.12 ± 0.12 2.47 ± 0.12** 2.35 ± 0.05** 2.24 ± 0.14* 2.19 ± 0.06
P mmol/L 3.31 ± 0.19 3.47 ± 0.25 3.50 ± 0.60 3.36 ± 0.40 3.64 ± 0.43 3.23 ± 0.45 3.36 ± 0.20 3.54 ± 0.15 3.53 ± 0.22
TG mmol/L 1.19 ± 0.21## 0.66 ± 0.09 0.78 ± 0.06 0.56 ± 0.09* 0.69 ± 0.16 0.71 ± 0.19 0.59 ± 0.15 0.58 ± 0.27* 0.77 ± 0.21
TCH mmol/L 1.37 ± 0.07## 1.98 ± 0.08 1.81 ± 0.23 1.53 ± 0.17** 1.93 ± 0.18 1.62 ± 0.12* 1.56 ± 0.18* 1.55 ± 0.26** 1.96 ± 0.29
  1. After the last measurement of thrombosis length at 48 h, blood was drawn from the heart. Serum samples were prepared by centrifugation and analyzed using an automatic biochemistry analyzer. # P < 0.05, ## P < 0.01 compared with the model group. *P < 0.05, **P < 0.01 compared with the CMC-Na group. AEE L: AEE 18 mg/kg; AEE M: 36 mg/kg; AEE H: AEE 72 mg/kg; Combination: combination of aspirin and eugenol (molar ratio 1:1)