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Table 3 Effect of AEE on platelet aggregation in k-carrageenan-induced rat tail thrombosis model (n = 10)

From: Evaluation on antithrombotic effect of aspirin eugenol ester from the view of platelet aggregation, hemorheology, TXB2/6-keto-PGF1α and blood biochemistry in rat model

Groups

AA-induced PAg

ADP-induced PAg

Control

8.70 ± 1.34##

31.90 ± 2.77##

Model

29.00 ± 1.49

50.10 ± 3.34

CMC-Na

30.10 ± 2.13

51.90 ± 2.28

Aspirin

20.44 ± 2.74**

40.89 ± 4.26**

Eugenol

27.10 ± 3.14*

50.10 ± 2.23

AEE L

18.70 ± 3.49**

49.30 ± 2.79

AEE M

11.80 ± 3.70**

43.30 ± 3.13**

AEE H

15.70 ± 3.43**

42.20 ± 3.26**

Combination

11.50 ± 2.50**

45.50 ± 3.17**

  1. 5 μM ADP and 5 mM AA were added separately to platelet-rich plasma (PRP), which was used to assess platelet aggregation. Results are expressed as the percentage of maximal aggregation. Data are expressed as mean ± SD. # P < 0.05, ## P < 0.01 compared with the model group. *P < 0.05, **P < 0.01 compared with the CMC-Na group. PAg: platelet aggregation. AEE L: AEE 18 mg/kg; AEE M: 36 mg/kg; AEE H: AEE 72 mg/kg; Combination: combination of aspirin and eugenol (molar ratio 1:1)
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BMC Veterinary Research

ISSN: 1746-6148

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