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Table 3 Effect of AEE on platelet aggregation in k-carrageenan-induced rat tail thrombosis model (n = 10)

From: Evaluation on antithrombotic effect of aspirin eugenol ester from the view of platelet aggregation, hemorheology, TXB2/6-keto-PGF and blood biochemistry in rat model

Groups AA-induced PAg ADP-induced PAg
Control 8.70 ± 1.34## 31.90 ± 2.77##
Model 29.00 ± 1.49 50.10 ± 3.34
CMC-Na 30.10 ± 2.13 51.90 ± 2.28
Aspirin 20.44 ± 2.74** 40.89 ± 4.26**
Eugenol 27.10 ± 3.14* 50.10 ± 2.23
AEE L 18.70 ± 3.49** 49.30 ± 2.79
AEE M 11.80 ± 3.70** 43.30 ± 3.13**
AEE H 15.70 ± 3.43** 42.20 ± 3.26**
Combination 11.50 ± 2.50** 45.50 ± 3.17**
  1. 5 μM ADP and 5 mM AA were added separately to platelet-rich plasma (PRP), which was used to assess platelet aggregation. Results are expressed as the percentage of maximal aggregation. Data are expressed as mean ± SD. # P < 0.05, ## P < 0.01 compared with the model group. *P < 0.05, **P < 0.01 compared with the CMC-Na group. PAg: platelet aggregation. AEE L: AEE 18 mg/kg; AEE M: 36 mg/kg; AEE H: AEE 72 mg/kg; Combination: combination of aspirin and eugenol (molar ratio 1:1)