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Table 2 Drug effects on hemorheological parameters in k-carrageenan-induced rat tail thrombosis model (n = 10)

From: Evaluation on antithrombotic effect of aspirin eugenol ester from the view of platelet aggregation, hemorheology, TXB2/6-keto-PGF1α and blood biochemistry in rat model

Groups

WBV (mPa.s)

PV (mPa.s)

Low shear rate (5 s−1)

Medium shear rate (100 s−1)

High shear rate (200 s−1)

Control

18.56 ± 3.03##

4.63 ± 0.77##

3.55 ± 0.79##

1.55 ± 0.28#

Model

27.75 ± 3.27

6.74 ± 0.78

5.24 ± 0.63

2.04 ± 0.47

CMC-Na

26.42 ± 2.66

6.87 ± 0.62

5.22 ± 0.52

1.97 ± 0.25

Aspirin

22.75 ± 3.57*

6.21 ± 0.62

5.21 ± 0.35

1.39 ± 0.13**

Eugenol

28.69 ± 2.93

6.87 ± 0.72

5.52 ± 0.79

1.63 ± 0.25*

AEE L

20.03 ± 2.75**

5.38 ± 0.78**

4.58 ± 0.67*

1.32 ± 0.12**

AEE M

22.60 ± 2.28**

5.48 ± 0.86**

4.74 ± 0.52

1.68 ± 0.61

AEE H

22.25 ± 3.60**

5.14 ± 0.69**

4.63 ± 0.62

1.50 ± 0.14**

Combination

27.45 ± 2.90

6.58 ± 1.06

5.28 ± 0.63

2.19 ± 0.30

  1. After the last measurement of rat tail thrombosis length at 48 h, 0.8 mL of whole blood and 0.5 mL of plasma were collected for hemorheological parameter tests. Data are expressed as mean ± SD. # P < 0.05, ## P < 0.01 compared with model group. *P < 0.05, **P < 0.01 compared with CMC-Na group. WBV whole blood viscosity, PV plasma viscosity. AEE L: AEE 18 mg/kg; AEE M: 36 mg/kg; AEE H: AEE 72 mg/kg; Combination: combination of aspirin and eugenol (molar ratio 1:1)
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BMC Veterinary Research

ISSN: 1746-6148

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