Skip to main content

Table 2 Drug effects on hemorheological parameters in k-carrageenan-induced rat tail thrombosis model (n = 10)

From: Evaluation on antithrombotic effect of aspirin eugenol ester from the view of platelet aggregation, hemorheology, TXB2/6-keto-PGF and blood biochemistry in rat model

Groups WBV (mPa.s) PV (mPa.s)
Low shear rate (5 s−1) Medium shear rate (100 s−1) High shear rate (200 s−1)
Control 18.56 ± 3.03## 4.63 ± 0.77## 3.55 ± 0.79## 1.55 ± 0.28#
Model 27.75 ± 3.27 6.74 ± 0.78 5.24 ± 0.63 2.04 ± 0.47
CMC-Na 26.42 ± 2.66 6.87 ± 0.62 5.22 ± 0.52 1.97 ± 0.25
Aspirin 22.75 ± 3.57* 6.21 ± 0.62 5.21 ± 0.35 1.39 ± 0.13**
Eugenol 28.69 ± 2.93 6.87 ± 0.72 5.52 ± 0.79 1.63 ± 0.25*
AEE L 20.03 ± 2.75** 5.38 ± 0.78** 4.58 ± 0.67* 1.32 ± 0.12**
AEE M 22.60 ± 2.28** 5.48 ± 0.86** 4.74 ± 0.52 1.68 ± 0.61
AEE H 22.25 ± 3.60** 5.14 ± 0.69** 4.63 ± 0.62 1.50 ± 0.14**
Combination 27.45 ± 2.90 6.58 ± 1.06 5.28 ± 0.63 2.19 ± 0.30
  1. After the last measurement of rat tail thrombosis length at 48 h, 0.8 mL of whole blood and 0.5 mL of plasma were collected for hemorheological parameter tests. Data are expressed as mean ± SD. # P < 0.05, ## P < 0.01 compared with model group. *P < 0.05, **P < 0.01 compared with CMC-Na group. WBV whole blood viscosity, PV plasma viscosity. AEE L: AEE 18 mg/kg; AEE M: 36 mg/kg; AEE H: AEE 72 mg/kg; Combination: combination of aspirin and eugenol (molar ratio 1:1)