Table 3 Schedule of study 2

Administration of test items and furosemide^a

Haematology, coagulation

−15

5

−15

12

Clinical chemistry

−15, −8

5

−15, −8

12

Urinalysis and water consumption

−14, −7^b

6

−14, −7^b

13

Body weight

−16, −13, −9, −6, −1

7

−16, −13, −9, −6, −1, 5

14

Feed consumption

−16 to −1

0 to 6

−16 to 6

7 to 14

Iohexol concentration

−8 (0, 2, 3 & 4 h)

6 (0, 2, 3 & 4 h)

−7 (0, 2, 3 & 4 h)

13 (0, 2, 3 & 4 h)

Plasma renin activity and aldosterone concentration

0^c 6 (0 h)

6 (2, 6, 12 & 24 h)

7^c 13 (0 h)

13 (2, 6, 12 & 24 h)