Association of anticardiolipin, antiphosphatidylserine, anti-β2 glycoprotein I, and antiphosphatidylcholine autoantibodies with canine immune thrombocytopenia

Table 2 Frequency of antiphospholipid antibodies among different groups of dogs based on the 98^th percentile cut-off

aPL subtype	I/I_A/I_B/I_C ^a	II^b	III^c	I/I_A/I_B/I_C	I/I_A/I_B/I_C
	n = 64/20/18/26	n = 30	n = 80	vs. II	vs. III
	positive (%)	positive (%)	positive (%)	relative risk (odds ratio)^{d, e}	relative risk (odds ratio)
aPhL	63/20/18/25 (98/100/100/96)	27 (90)	2 (3)	2.8/(5.2)/(4.7)/1.9	76 ^*/(1287)^/(1162)^/73 ^*
aβ₂GPI	52/17/15/20 (81/85/83/77)	16 (53)	3 (4)	1.6^/2.9** ^/2.7*/1.8	7.0 ^*/22 ^/22 ^/12 ^*
aCL	63/19/18/26 (98/95/100/100)	20 (67)	3 (4)	8.3 ^*/5.3** ^/(19)^/(27)^**	74 ^*/67 ^/(819)* ^*/(1174) ^*
aPI	30/8/12/10 (47/40/67/38)	7 (23)	4 (5)	1.3^/1.5/2.4* ^*/1.4	2.8 ^*/4.8 ^/10 ^/4.1 ^*
aPC	38/13/12/13 (59/65/67/50)	9 (30)	4 (5)	1.4^/2.3* ^/2.5* ^*/1.5	3.5 ^*/9.0 ^/10 ^/5.2 ^*
aPS	50/16/15/19 (78/80/83/73)	14 (47)	5 (6)	1.6^/2.6** ^/3.2* ^*/1.8	5.7 ^*/15 ^/19 ^/9.2 ^*

^aSubgroups of Group I (thrombocytopenia): I_A (immune thrombocytopenia, aPLT⁺, platelet < 30 × 10³/uL), I_B (severe thrombocytopenia, aPLT^-, platelet < 30 × 10³/uL), and I_C (less severe thrombocytopenia, platelet 30 – 80 × 10³/uL). ^bGroup II: outpatient dogs without thrombocytopenia. ^cGroup III: healthy dogs. ^dOdds ratio is shown in parenthesis if relative risk is ∞. ^eValue > 2 is shown in bold. ^*Frequencies are significantly different (^* P < 0.05; ^** P < 0.01; ^*** P ≤ 0.001)

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