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Table 2 Frequency of antiphospholipid antibodies among different groups of dogs based on the 98th percentile cut-off

From: Association of anticardiolipin, antiphosphatidylserine, anti-β2 glycoprotein I, and antiphosphatidylcholine autoantibodies with canine immune thrombocytopenia

aPL subtype I/IA/IB/IC a IIb IIIc I/IA/IB/IC I/IA/IB/IC
n = 64/20/18/26 n = 30 n = 80 vs. II vs. III
positive (%) positive (%) positive (%) relative risk (odds ratio)d, e relative risk (odds ratio)
aPhL 63/20/18/25 (98/100/100/96) 27 (90) 2 (3) 2.8/(5.2)/(4.7)/1.9 76 ***/(1287)***/(1162)***/73 ***
2GPI 52/17/15/20 (81/85/83/77) 16 (53) 3 (4) 1.6**/2.9 */2.7/1.8 7.0 ***/22 ***/22 ***/12 ***
aCL 63/19/18/26 (98/95/100/100) 20 (67) 3 (4) 8.3 ***/5.3 */(19)**/(27)*** 74 ***/67 ***/(819) ***/(1174) ***
aPI 30/8/12/10 (47/40/67/38) 7 (23) 4 (5) 1.3*/1.5/2.4 */1.4 2.8 ***/4.8 ***/10 ***/4.1 ***
aPC 38/13/12/13 (59/65/67/50) 9 (30) 4 (5) 1.4*/2.3 */2.5 */1.5 3.5 ***/9.0 ***/10 ***/5.2 ***
aPS 50/16/15/19 (78/80/83/73) 14 (47) 5 (6) 1.6**/2.6 */3.2 */1.8 5.7 ***/15 ***/19 ***/9.2 ***
  1. aSubgroups of Group I (thrombocytopenia): IA (immune thrombocytopenia, aPLT+, platelet < 30 × 103/uL), IB (severe thrombocytopenia, aPLT-, platelet < 30 × 103/uL), and IC (less severe thrombocytopenia, platelet 30 – 80 × 103/uL). bGroup II: outpatient dogs without thrombocytopenia. cGroup III: healthy dogs. dOdds ratio is shown in parenthesis if relative risk is ∞. eValue > 2 is shown in bold. *Frequencies are significantly different (* P < 0.05; ** P < 0.01; *** P ≤ 0.001)