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Table 1 Average IgG levels of antiphospholipid antibodies (aPL) among different groups of dogs

From: Association of anticardiolipin, antiphosphatidylserine, anti-β2 glycoprotein I, and antiphosphatidylcholine autoantibodies with canine immune thrombocytopenia

aPL subtype IA a IB IC IId IIIe 98th/99thpercentile cut-off GPL
(n = 20) (n = 18) (n = 26) (n = 30) (n = 80)
GPLb (95 % CI)c GPL (95 % CI) GPL (95 % CI) GPL (95 % CI) GPL (95 % CI)
aPhL 95.9 (79.3 – 112.5) 116.7 (99.4 – 134.0) 130.9 (105.2 – 156.6) 66.8 (56.5 – 77.0) 7.4 (5.8 – 9.1) 23.1/25.4
2GPI 65.7 (50.6 – 80.7) 40.8 (30.2 – 51.4) 64.9 (44.6 – 85.2) 40.4 (29.0 – 51.8) 6.1 (4.0 – 8.3) 26.7/30.4
aCL 38.8 (28.8 – 48.8) 49.6 (34.3 – 65.0) 58.9 (43.8 – 73.9) 18.3 (11.9 – 24.8) 0.8 (0.2 – 1.3) 5.6/7.1
aPI 18.5 (12.6 – 24.3) 24.4 (19.2 – 29.7) 17.1 (10.8 – 23.4) 15.6 (11.4 – 19.8) 4.2 (2.4 – 5.9) 20.3/23.6
aPC 21.0 (14.5 – 27.4) 17.4 (12.7 – 22.1) 17.5 (12.6 – 22.3) 11.8 (8.4 – 15.2) 3.2 (2 – 4.4) 15.7/17.5
aPS 16.8 (11.0 – 22.5) 18.0 (12.9 – 23.0) 13.5 (8.4 – 18.6) 11.2 (6.3 – 16.2) 0.8 (0.2 – 1.4) 5.6/7.3
  1. aSubgroups of Group I (thrombocytopenia): IA (immune thrombocytopenia, aPLT+, platelet < 30 × 103/uL), IB (severe thrombocytopenia, aPLT-, platelet < 30 × 103/uL), and IC (less severe thrombocytopenia, platelet 30 – 80 × 103/uL). bConcentrations (μg/mL of IgG, GPL) were converted directly from the OD readings based on the equation shown in Fig. 1a. One GPL unit is defined as the binding activity of 1 μg/mL of IgG. c95% confidence interval. dOutpatient dogs without thrombocytopenia (Group II). eHealthy dogs (Group III)