|
aPL subtype
|
IA
a
|
IB
|
IC
|
IId
|
IIIe
|
98th/99thpercentile cut-off GPL
|
|---|
|
(n = 20)
|
(n = 18)
|
(n = 26)
|
(n = 30)
|
(n = 80)
|
|---|
|
GPLb (95 % CI)c
|
GPL (95 % CI)
|
GPL (95 % CI)
|
GPL (95 % CI)
|
GPL (95 % CI)
|
|---|
|
aPhL
|
95.9 (79.3 – 112.5)
|
116.7 (99.4 – 134.0)
|
130.9 (105.2 – 156.6)
|
66.8 (56.5 – 77.0)
|
7.4 (5.8 – 9.1)
|
23.1/25.4
|
|
aβ2GPI
|
65.7 (50.6 – 80.7)
|
40.8 (30.2 – 51.4)
|
64.9 (44.6 – 85.2)
|
40.4 (29.0 – 51.8)
|
6.1 (4.0 – 8.3)
|
26.7/30.4
|
|
aCL
|
38.8 (28.8 – 48.8)
|
49.6 (34.3 – 65.0)
|
58.9 (43.8 – 73.9)
|
18.3 (11.9 – 24.8)
|
0.8 (0.2 – 1.3)
|
5.6/7.1
|
|
aPI
|
18.5 (12.6 – 24.3)
|
24.4 (19.2 – 29.7)
|
17.1 (10.8 – 23.4)
|
15.6 (11.4 – 19.8)
|
4.2 (2.4 – 5.9)
|
20.3/23.6
|
|
aPC
|
21.0 (14.5 – 27.4)
|
17.4 (12.7 – 22.1)
|
17.5 (12.6 – 22.3)
|
11.8 (8.4 – 15.2)
|
3.2 (2 – 4.4)
|
15.7/17.5
|
|
aPS
|
16.8 (11.0 – 22.5)
|
18.0 (12.9 – 23.0)
|
13.5 (8.4 – 18.6)
|
11.2 (6.3 – 16.2)
|
0.8 (0.2 – 1.4)
|
5.6/7.3
|
-
aSubgroups of Group I (thrombocytopenia): IA (immune thrombocytopenia, aPLT+, platelet < 30 × 103/uL), IB (severe thrombocytopenia, aPLT-, platelet < 30 × 103/uL), and IC (less severe thrombocytopenia, platelet 30 – 80 × 103/uL). bConcentrations (μg/mL of IgG, GPL) were converted directly from the OD readings based on the equation shown in Fig. 1a. One GPL unit is defined as the binding activity of 1 μg/mL of IgG. c95% confidence interval. dOutpatient dogs without thrombocytopenia (Group II). eHealthy dogs (Group III)
