TY - JOUR AU - Ibrahim, Mohd Rafiq Mohd AU - Singh, Simmrat AU - Merican, Azhar Mahmood AU - Raghavendran, Hanumantha Rao Balaji AU - Murali, Malliga Raman AU - Naveen, Sangeetha Vasudevaraj AU - Kamarul, Tunku PY - 2016 DA - 2016/06/16 TI - The effect of strontium ranelate on the healing of a fractured ulna with bone gap in rabbit JO - BMC Veterinary Research SP - 112 VL - 12 IS - 1 AB - Fracture healing in bone gap is one of the major challenges encountered in Orthopedic Surgery. At present, the treatment includes bone graft, employing either internal or external fixation which has a significant impact on the patient, family and even society. New drugs are emerging in the markets such as anabolic bone-forming agents including teriparatide and strontium ranelate to stimulate bone growth. Based on the mechanism of their actions, we embarked on a study on the healing of a fractured ulna with bone gap in a rabbit model. We segregated ten rabbits into two groups: five rabbits in the test group and five rabbits in the control group. We created a 5 mm bone gap in the ulna bone, removing the periosteum as well. Rabbits in the test group received 450 mg/kg of strontium ranelate via oral administration, daily, for six weeks. The x-rays, CT scans and blood tests were performed every two weeks. At the end of six weeks, the rabbits were sacrificed, and the radius and ulna bones harvested for histopathological examination. SN - 1746-6148 UR - https://doi.org/10.1186/s12917-016-0724-6 DO - 10.1186/s12917-016-0724-6 ID - Ibrahim2016 ER -