TY - JOUR AU - Bertrand, Henri G. M. J. AU - Ellen, Yvette C. AU - O’Keefe, Stevie AU - Flecknell, Paul A. PY - 2016 DA - 2016/06/08 TI - Comparison of the effects of ketamine and fentanyl-midazolam-medetomidine for sedation of rhesus macaques (Macaca mulatta) JO - BMC Veterinary Research SP - 93 VL - 12 IS - 1 AB - This study assessed the effects of sedation using a combination of fentanyl, midazolam and medetomidine in comparison to ketamine. Rhesus Macaques (Macaca mulatta), (n = 16, 5 males and 3 females randomly allocated to each treatment group) received either ketamine (KET) (10 mg.kg−1) or fentanyl-midazolam-medetomidine (FMM) (10 μg/kg−1; 0.5 mg.kg−1; 20 μg.kg−1) both IM. Oxygen (100 %) was provided by mask and heart rate, blood pressure, respiratory rate, EtCO2 and depth of sedation were assessed every 5 min for 20 min. After the last time point, FMM monkeys were reversed with atipamezole-naloxone (0.2 mg.kg−1; 10 μg.kg−1). Recovery was scored using clinical scoring scheme. Differences in physiological parameters and quality of sedation were compared using Area Under the Curve (AUC) method and either Mann-Witney or t-student tests. SN - 1746-6148 UR - https://doi.org/10.1186/s12917-016-0721-9 DO - 10.1186/s12917-016-0721-9 ID - Bertrand2016 ER -