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Fig. 1 | BMC Veterinary Research

Fig. 1

From: Epidemiology, presentation and population genetics of patent ductus arteriosus (PDA) in the Dutch Stabyhoun dog

Fig. 1

Histopathology of PDA in Stabyhoun dogs. a Picosirius red with Alcian blue: Wall of the persistent ductus arteriosus adjacent to the aorta showing approximately evenly distributed collagen and GAG-rich extracellular matrix. ×100. b Picosirius red and Alcian blue: Wall of the PDA adjacent to the pulmonary artery; the collagen is irregularly arranged with short crisscrossing bundles separated by irregular deposits of GAG-rich extracellular matrix. ×100. c Smooth muscle actin: Wall of the persistent ductus arteriosus adjacent to the aorta with immunohistochemical staining of smooth muscle actin highlighting the concentric and relatively even distribution of smooth muscle cells. ×100. d Smooth muscle actin: Wall of the persistent ductus arteriosus adjacent to the pulmonary artery; bundles of smooth muscle cells are short and irregularly distributed. ×100

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