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Table 2 Romiplostim therapy in five dogs with primary and secondary immune thrombocytopenia: Dosage, response and outcome

From: Treatment of 5 dogs with immune-mediated thrombocytopenia using Romiplostim

Dog Current therapy at the commencement of romiplostim Platelets count
x103/μl
Romiplostim
μg/kg (initial dose)
Response Maintenance therapy Outcome
Day Platelets count
x103/μl
1 pred 0.5 mg/kg twice daily
MMF 5 mg/kg twice daily
19 5 6 / 73 13 / 226 2.3 μg romi CR > 10 mon
2 pred 0.6 mg/kg twice daily 57 3 3 / 83
5 / 131
8 / 222
15 / 332
now 2 μg/kg romi
0.1 mg/kg pred every other daya
CR > 3 mon
3 pred 0.6 mg/kg twice daily
MMF 5 mg/kg twice daily
25 5 4
7
10
58
189
217
2.5 μg ITP CR
but euthanized due to AIHA after 2.5 mon
4 pred 0.5 mg/kg twice daily 123 4.5 3 / 178 5 / 213  3.4 CR > 5 mon
5 a) pred 0.4 mg/kg once daily, doxycycline
b) 2 months later: pred 0.5 mg/kg, amoxicillin
a) 4
b) 1
a) 5.3
b) 13
a) No response
b) 4
 11
 15

7
3
115
  b) Lost for follow-up
  1. Romi romiplostim, pred prednisolone, MMF mycofenolate mofetil, CR complete remission (platelet counts > 200 × 103/μl), ITP immune thrombocytopenia, AIHA autoimmune hemolytic anemia, mon months
  2. adue to autoimmune hemolysis