Table 2 Romiplostim therapy in five dogs with primary and secondary immune thrombocytopenia: Dosage, response and outcome
From: Treatment of 5 dogs with immune-mediated thrombocytopenia using Romiplostim
Dog | Current therapy at the commencement of romiplostim | Platelets count x103/μl | Romiplostim μg/kg (initial dose) | Response | Maintenance therapy | Outcome | |
|---|---|---|---|---|---|---|---|
Day | Platelets count x103/μl | ||||||
1 | pred 0.5 mg/kg twice daily MMF 5 mg/kg twice daily | 19 | 5 | 6 / 73 | 13 / 226 | 2.3 μg romi | CR > 10 mon |
2 | pred 0.6 mg/kg twice daily | 57 | 3 | 3 / 83 5 / 131 | 8 / 222 15 / 332 | now 2 μg/kg romi 0.1 mg/kg pred every other daya | CR > 3 mon |
3 | pred 0.6 mg/kg twice daily MMF 5 mg/kg twice daily | 25 | 5 | 4 7 10 | 58 189 217 | 2.5 μg | ITP CR but euthanized due to AIHA after 2.5 mon |
4 | pred 0.5 mg/kg twice daily | 123 | 4.5 | 3 / 178 | 5 / 213 | 3.4 | CR > 5 mon |
5 | a) pred 0.4 mg/kg once daily, doxycycline b) 2 months later: pred 0.5 mg/kg, amoxicillin | a) 4 b) 1 | a) 5.3 b) 13 | a) No response b) 4 11 15 | ᅟ 7 3 115 | b) Lost for follow-up | |