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Table 1 Signalment and history of five dogs with primary and secondary immune thrombocytopenia treated with romiplostim

From: Treatment of 5 dogs with immune-mediated thrombocytopenia using Romiplostim

Dog

Signalment

ITP – diagnoses

month/year

Recurrences

Previous immunosuppressive therapy

Therapy (in addition to immunosuppressive medication)

1

Bearded Collie

7-year-old, female

22 kg

7/2012: primary ITP

1) 10/2012

2) 3/2013

3) 9/2014

4) 10/2014

pred 1 mg/kg twice daily + MMF 8 mg/kg twice daily

Recurrence 1) Pred, cyclosporine

2) only pred

3) pred, MMF, then dexamethasone

4) pred, MMF

omeprazole, sucralfate (to prevent gastrointestinal ulcers)

ursodeoxycholic acid (due to increase in liver enzymes)

2

Border Collie

10-year-old, female-spayed

25 kg (obese)

2014: primary AIHA

5/2015: Evans’ syndrome (primary ITP and AIHA)

after 3 weeks

short-acting methyl-pred 10 mg/kg once, pred 0.8 mg/kg twice daily

doxycycline

omeprazole, sucralfate

3

Poodle

3-year-old, male-neutered

25 kg

12/2014: Evans’ syndrome (primary ITP and AIHA)

after 3 weeks

pred 1.5 mg/kg twice daily, MMF 5 mg/kg twice daily

omeprazole, sucralfate

4

Mixed-breed

3-year-old, female-spayed, 22 kg

ITP associated with

monocytic ehrlichiosis

after 4 weeks

pred 1 mg/kg twice daily

doxycycline

omeprazole, sucralfate

5

Mixed-breed

2.5-year-old, female

14 kg

ITP associated with monocytic ehrlichiosis

2 weeks

pred 0.4 mg/kg once daily

chloramphenicole/imidocarb

amoxicillin-clavulanic acid

omeprazole, sucralfate

ursodeoxycholic acid

S-adenosyl-methionine

  1. Pred prednisolone, MMF mycofenolate mofetil, ITP immune thrombocytopenia, AIHA autoimmune hemolytic anemia