Skip to main content
Fig. 4 | BMC Veterinary Research

Fig. 4

From: Canine influenza virus coinfection with Staphylococcus pseudintermedius enhances bacterial colonization, virus load and clinical presentation in mice

Fig. 4

Histopathological lesions at 2 days post Sp challenge in the co-infected group, shown by H&E staining in the brain, spleen and lung of mice infected with CIV alone, S. pseudintermedius alone, or both. a Representative brain image from the CIV-only group, showing diffused hyperplasia of microglial cells and disintegration of neuron cells (400×). b Representative brain image from the Sp-only group, showing dissolution of nerve fibres, vascular cuff phenomena and neurophagia phenomena (400×). c Representative brain image from the CIV/Sp group, showing nerve fibre dissolution and disappearance of neurons (400×). e Representative spleen image from the CIV-only group, showing no lesions (100×). f Representative spleen image from the Sp-only group, showing hyperplasia of the splenic trabeculae (100×). g Representative spleen image from the CIV/Sp group, showing hyperplasia and degeneration of the splenic trabeculae (100×). i Representative lung image from the CIV-only group, showing widening of the pulmonary interstitial (100×). j Representative lung image from the Sp-only group, showing widening of the alveolar septa (100×). k Representative lung image from the CIV/Sp group, showing severe fibrin exudation, appearance of neutrophils and widening of the alveolar septa (100×). d, h, l Representative brain, spleen and lung images of the control group, showing no histopathological lesions (400×, 400× and 100×)

Back to article page