A randomised, double-blinded, placebo-controlled clinical study on intra-articular hyaluronan treatment in equine lameness originating from the metacarpophalangeal joint

Table 2 Medians (and ranges) of outcome measures in the placebo and NASHA groups, with P-values for the within-groups comparison of outcome measures between the first baseline and second clinical (end) examination, and P-values for the comparison between groups (P of change between interventions) of the change in outcome measures after the second clinical examination

Outcome measure	Placebo baseline	Placebo end	P within placebo	NASHA baseline	NASHA end	P within NASHA	P for change between interventions
Lameness^a	2 (1–3)	2 (0–3)	0.005	2 (1–3)	0 (0–3)	0.02	0.94
Effusion^b	1 (0–3)	1 (0–3)	0.48	1 (0–3)	1 (0–3)	0.56	0.94
Flexion test^c	3 (2–4)	3 (1–4)	0.07	3 (2–4)	1 (0–3)	0.002	0.01
Pain^d	2 (1–3)	1 (0–3)	0.04	2 (0–3)	0 (0–2)	0.01	0.27

^a AAEP scale 0–5
^b 0 = no effusion, 1 = mild, 2 = moderate, 3 = severe effusion, 4 = severe swelling of the metacarpal joint region
^c 0 = no increase,1 = slight increase, 2 = moderate increase, 3 = considerable increase in baseline lameness, 4 = non-weight-bearing lameness
^d 0 = no pain at flexion, 1 = mild pain, 2 = moderate pain, 3 = severe pain

ISSN: 1746-6148