Table 2 Descriptive statistics for pharmacokinetic parameters
Treatment type | kel | t1/2 | Tmax | Cmax | AUC0-t | AUCtot | % AUC 0-∞ | |
|---|---|---|---|---|---|---|---|---|
(1/h) | (h) | (h) | (ng/mL) | (h.ng/ml) | (h.ng/ml) | (%) | ||
Atopica® soft capsules | Mean | 0.076 | NA | 1.24 | 772.18 | 3680 | 3901 | 5.8 |
SD | 0.037 | NA | 0.32 | 163.8 | 1263 | 1336 | 1.4 | |
CV% | 49.4 | NA | 25.6 | 21.2 | 34.3 | 34.3 | 23.3 | |
Harmonic Mean | 0.066 | 9.13 | 1.16 | 734.53 | 3279 | 3489 | 5.5 | |
Min | 0.044 | 3.23 | 0.50 | 361.39 | 1236 | 1334 | 3.5 | |
Max | 0.214 | 15.75 | 2.00 | 1121.98 | 7763 | 8393 | 8.5 | |
Cyclavance® oral solution | Mean | 0.073 | NA | 1.12 | 786.97 | 3728 | 3955 | 5.8 |
SD | 0.026 | NA | 0.36 | 188.3 | 1243 | 1305 | 1.3 | |
CV% | 35.7 | NA | 32.5 | 23.9 | 33.3 | 33 | 22.3 | |
Harmonic Mean | 0.064 | 9.55 | 1 | 736.31 | 3339 | 3549 | 5.6 | |
Min | 0.030 | 5.56 | 0.50 | 334.61 | 1654 | 1740 | 3.7 | |
Max | 0.125 | 23.08 | 2.00 | 1106.28 | 6907 | 7170 | 9.8 |