Table 2 Median pharmacokinetic parameters with lower and upper confidence intervals of meloxicam in control and surgery groups following intravenous (0.2 mg/kg) administration to bitches (n = 8)

T_1/2λz (h)

17.21 (12.8–40.1)

12.77 (9.8–24.3)

0.289

C₀ (μg/ml)

1.05 (0.7–9.92)

5.3 (1.9–14.2)

0.298

AUC_last (μg.h/ml)

21.2 (10.8–30.8)

28.5 (18.7–45.6)

0.176

AUC_0→∞ (μg.h/ml)

23.0 (12.4–41.0)

29.5 (19.4–51.5)

0.322

AUMC_0→∞ (μg.h²/ml)

698 (378–2815)

588 (329–2150)

0.959

Cl _B (ml.h/kg)

10.5 (6.0–20.6)

7.7 (4.9–11.35)

0.191

Vd_ss (ml/kg)

263.0 (211–470)

149.3 (122.4–172.7)

0.016*

MRT_0→∞ (h)

28.1 (19.5–56.0)

20.7 (14.4–34.3)

0.303