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Table 4 Serum biomarker concentrations in dogs fed a diet with a low or adequate selenium concentration

From: Biomarkers of selenium status in dogs

Diet

Week

Adequate-Se

Low-Se

p-value

n

mean

SE

n

mean

SE

Serum Se (Ī¼g/L)

0

12

263

5.3

12

263

4.7

0.987

1

12

271

5.8

11

252

6.1

0.030

2

12

263

3.6

12

245

6.0

0.029

3

12

266

4.5

12

249

6.1

0.050

4

12

261

4.5

12

236

3.5

0.000

5

12

247

5.1

12

240

8.3

0.853

6

12

248

4.6

12

230

6.4

0.024

7

11

254

5.8

12

230

5.7

0.000

8

12

243

4.7

12

224

4.1

0.013

Serum GPx (U/L)

0

12

14884

383

12

15027

323

0.778

1

12

14754

355

11

14175

251

0.228

2

12

15274

353

12

14563

380

0.101

3

12

14726

309

12

14066

296

0.143

4

12

14215

315

12

13644

304

0.250

5

12

14421

304

12

14330

255

0.998

6

12

14968

287

12

14007

313

0.012

7

11

15052

349

12

14459

232

0.232

8

12

15755

375

12

14579

271

0.001

Serum CK (U/L)

0

12

76

5.6

12

75

6.1

0.912

1

10

79

6.3

10

75

5.2

1.000

2

12

73

7.2

12

72

6.7

1.000

3

12

84

10.7

11

75

5.9

0.965

4

12

61

7.7

12

58

3.3

1.000

5

12

45

4.4

12

54

5.2

0.837

6

12

60

8.8

12

51

4.6

0.858

7

11

52

3.8

11

56

4.5

1.000

8

12

52

2.9

12

54

4.0

1.000

Serum T3:T4

0

12

0.031

0.001

12

0.029

0.001

0.093

1

11

0.031

0.001

11

0.029

0.001

0.998

2

12

0.031

0.001

12

0.031

0.001

0.987

3

12

0.034

0.001

11

0.033

0.001

1.000

4

12

0.038

0.001

12

0.033

0.001

0.144

5

12

0.034

0.001

12

0.033

0.001

0.999

6

12

0.034

0.001

12

0.031

0.001

0.900

7

11

0.035

0.001

12

0.033

0.001

0.997

8

12

0.036

0.001

12

0.035

0.001

0.996

Serum Cu:Cu intake

0

12

15.8

1.0

12

19.3

1.2

0.033

1

7

32.1

2.5

8

22.8

3.5

0.985

2

8

21.4

1.5

11

18.2

1.0

1.000

3

12

23.2

1.6

10

20.0

1.0

0.944

4

11

26.7

2.2

12

20.2

1.3

0.919

5

12

17.4

0.8

12

14.8

0.7

0.999

6

11

16.4

1.0

10

13.5

0.7

1.000

7

8

17.5

1.0

6

13.1

1.0

1.000

8

12

19.6

1.3

11

15.4

0.7

1.000

  1. Se selenium, n number of dogs, SE standard error, GPx glutathione peroxidase, CK creatine kinase, T3 triiodothyronine, T4 thyroxine, Cu copper
  2. Values at weeks zero indicate the average baseline values. Means and standard errors are based on the raw data