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Table 1 Sample classification details

From: Inflammatory profiles in canine intervertebral disc degeneration

Samples biochemistry Samples histopathology
# Dogs CD dogs NCD dogs # Dogs CD dogs NCD dogs
58 40 15 10
Age – median 5 years 2 years Age – median (range(yrs)) 10 year 7 years
(range(mths – yrs)) (1–11 ) (8–12) (2–10) (1–10)
Spinal location NP AF NP AF Spinal location
# IVDs 35 30 36 41 # IVDs 19 18
Cervical (C1 – T1) 13 21 10 16 Cervical (C1 – T1) ND ND
Thoracolumbar (T1 – L1) 21 12 2 ND Thoracolumbar (T1 – L1) 5 8
Lumbar (L1 – S1) 11 7 23 25 Lumbar (L1 – S1) 14 10
Unknown 7 7 1 ND Unknown ND ND
Degeneration Degeneration
Grade 1 (non-surgical) ND ND 9a 10a Grade 1 2 8
Grade 2 32b 32c 9 9 Grade 2 4 7
Grade 3 7 6 8 8 Grade 3 3 3
Grade 4 + 5 13d 9d 10 12 + 2 Grade 4 + 5 3 + 3 3
Displacement Displacement
NP in situ (non-surgical) 27b,c 27b,c 9a 10a NP in situ ND
Nuclear extrusion 24 18 12 7 Nuclear extrusion ND
Annular protrusion 1 2 15 24 Annular protrusion ND
Treatment Treatment
No treatment 9 9 14 20 No treatment ND
Treatment 24 21 20 20   
 NSAID < 1 wk 7 8 7 4 NSAID < 1 wk ND
 NSAID > 1 wk 6 7 8 9 NSAID > 1 wk ND
 Steroids < 1 wk 4 2 1 ND Steroids < 1 wk ND
 Steroids > 1 wk 4 3 2 2 Steroids > 1 wk ND
 Other medication 3 1 2 5 Other medication ND
Unknown 2 ND 2 1 Unknown ND
  1. aSamples collected from experimental dogs
  2. b9 samples collected from experimental dogs (non-surgical); 17 samples collected in a previous study [40]
  3. c4 samples collected from experimental dogs (non-surgical); 17 samples collected in a previous study [40]
  4. d1 sample collected via fenestration
  5. eSamples collected from experimental dogs;17 samples collected in a previous study [40]