Fig. 3
From: Inflammatory profiles in canine intervertebral disc degeneration
Mean + standard deviation PGE2 levels normalized for DNA content in the nucleus pulposus (NP) and annulus fibrosus (AF) in Pfirrmann grade II samples obtained from experimental chondrodystrophic (CD) dogs (a), and in the complete dataset (CD and nonchondrodystrophic (NCD) dogs) per Pfirrmann grade (b), and per herniation (c). a. PGE2 levels expressed as pg/μg DNA in the NP of CD dogs were significantly higher in extruded grade II samples compared with NP in situ samples. b. PGE2 levels normalized for DNA were significantly lower in grade I samples compared with grade II, III, and IV + V samples regardless of the tissue origin (NP/AF), dog group (CD/NCD), or treatment group (no treatment, NSAID < 1 wk, NSAID > 1 wk, corticosteroids (cort) < 1 wk, cort > 1 wk, other). c. PGE2 levels expressed as pg/μg DNA were significantly lower in non-herniated samples compared with extruded and protruded samples in NCD dogs, regardless of the tissue origin (NP/AF), or treatment group (no treatment, NSAID < 1 wk, NSAID > 1 wk, corticosteroids (cort) < 1 wk, cort > 1 wk, other). ** Indicate significant difference at a 99 % confidence level