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Table 3 The PK/PD parameter estimates for the fAUC/MIC index and the fAUC/MIC required for various antibacterial effects

From: Pharmacokinetics/pharmacodynamics of marbofloxacin in a Pasteurella multocida serious murine lung infection model

Parameter

Unit

Mean ± SD

Emax

log10CFU/lung

2.08 ± 0.26

E0

log10CFU/lung

−4.67 ± 0.32

fAUC/MIC for EC50

h

91.08 ± 16.49

fAUC/MIC for static effect

h

40.84

fAUC/MIC for 1 log10 kill

h

76.88

fAUC/MIC for 2 log10 kill

h

139.34

fAUC/MIC for 3 log10 kill

h

278.08