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Table 2 Total bacterial populations after 24-h exposure to different doses of marbofloxacin

From: Pharmacokinetics/pharmacodynamics of marbofloxacin in a Pasteurella multocida serious murine lung infection model

Treatment group and time point Total dose (mg/kg) Bacterial population (mean ± SD) (log10 CFU/lung)
Untreated controls 0  
At start of treatmenta   7.12 ± 0.12
24 h after inoculationb   9.07 ± 0.19
24 h after start of treatment   **
Single administration 0.625 7.79 ± 0.56
  1 6.87 ± 0.91
  1.25 6.31 ± 0.74
  2 5.20 ± 0.74
  2.5 4.97 ± 0.52
  4 4.88 ± 0.41
  5 4.14 ± 0.49
  8 3.64 ± 0.63
  10 3.40 ± 0.32
  1. aTotal bacterial population 10 h after the time of infection
  2. b24 h after the inoculation was the time that the mice approached to death, and the lungs were removed for calculation the bacterial population
  3. **The mice were already dead