Pharmacokinetics/pharmacodynamics of marbofloxacin in a Pasteurella multocida serious murine lung infection model

Table 2 Total bacterial populations after 24-h exposure to different doses of marbofloxacin

Treatment group and time point	Total dose (mg/kg)	Bacterial population (mean ± SD) (log₁₀ CFU/lung)
Untreated controls	0
At start of treatment^a		7.12 ± 0.12
24 h after inoculation^b		9.07 ± 0.19
24 h after start of treatment		**
Single administration	0.625	7.79 ± 0.56
	1	6.87 ± 0.91
	1.25	6.31 ± 0.74
	2	5.20 ± 0.74
	2.5	4.97 ± 0.52
	4	4.88 ± 0.41
	5	4.14 ± 0.49
	8	3.64 ± 0.63
	10	3.40 ± 0.32

^aTotal bacterial population 10 h after the time of infection
^b24 h after the inoculation was the time that the mice approached to death, and the lungs were removed for calculation the bacterial population
**The mice were already dead

ISSN: 1746-6148