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Table 1 Pharmacokinetic parameters obtained from plasma concentrations after administration of marbofloxacin in infected neutropenic mice

From: Pharmacokinetics/pharmacodynamics of marbofloxacin in a Pasteurella multocida serious murine lung infection model

Marbofloxacin dose (mg/kg) Cmax mean ± SD (μg/ml) Tmax (h) AUC (μg.h/ml) Cl (ml kg−1 h−1) T1/2 (h)
1.25 0.66 ± 0.07 0.75 2.92 411.2 5.40
2.5 1.14 ± 0.14 0.75 5.73 420.3 5.23
5 2.13 ± 0.22 0.75 12.05 400.9 5.00
10 4.83 ± 0.30 0.75 23.90 408.9 4.29
  1. Cmax: maximum concentration of drug in plasma
  2. Tmax: time to maximum concentration of drug in plasma
  3. AUC: area under the concentration-time curve
  4. Cl: clearance
  5. T1/2: half-life