Fig. 1

Pharmacokinetic profiles of marbofloxacin in neutropenic mice. The neutropenic mice were infected with P. multocida as described above, and 10 h later administered with single subcutaneous doses of 1.25, 2.5, 5, or 10 mg/kg marbofloxacin in 0.2 mL volumes. Groups of four mice were each sampled by retro-orbital puncture at 0.083, 0.25, 0.5, 0.75, 1, 2, 4, 6, 8, 12, 24 h after dosing. Marbofloxacin concentrations were determined using a HPLC method with fluorescence detection. Each symbol represents the mean ± standard deviation of the levels in the sera of three mice