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Table 1 COX-1 and COX-2 scores in the kidney of normal young and old cats

From: Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney

COX-1 immunostaining Young (n = 10) Old (n = 11)
Thick limb 1.37 [1.01–1.66] 1.75 [1.43–1.81]
Collecting duct 1.32 [0.98–1.82] 1.41 [1.25–1.66]
Distal tubule 1.10 [0.84–1.35] 1.14 [1.00–1.43]
Thin limb 0.97 [0.58–1.20] 1.42 [0.82–1.55]
Macula densa 0.75 [0.55–0.81] 0.82 [0.80–1.13]
Proximal tubule 0.56 [0.44–0.71] 0.74 [0.36–0.91]
Glomerulus 0.48 [0.09–1.01] 0.70 [0.15–1.00]
Arteriole 0.50 [0.28–0.80] 0.60 [0.40–0.70]
Medullary interstitial cell 0.00 [0.0–0.25] 0.00 [0.00–0.00]
COX-2 immunostaining Young (n = 10) Old (n = 11)
Macula densa 1.29 [0.71–2.18] 1.32 [1.00–2.03]
Thin limb 1.16 [0.65–1.64] 1.10 [0.75–1.64]
Thick limb 1.10 [0.77–1.19] 0.93 [0.75–1.16]
Proximal tubule 0.73 [0.41–0.85] 1.19 [0.72–1.30]
Medullary interstitial cell 1.00 [0.00–1.00] 1.00 [0.00–1.00]
Collecting duct 0.81 [0.38–1.12] 0.90 [0.60–1.01]
Distal tubule 0.45 [0.27–1.13] 0.86 [0.42–1.09]
Glomerulus 0.75 [0.31–1.41] 0.80 [0.65–2.00]
Arteriole 0.15 [0.00–2.23] 0.10 [0.00–0.30]
  1. For each cat, an average intensity score for each structure was calculated as described in the methods section (range 0 to 3). This single value has been used to calculate the median [interquartile range] value presented in the table for each group of cats. There was no difference in expression between young and old cats for either isoenzyme (P > 0.05)