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Table 1 Summary of studies that investigated the effect of lysine on FHV-1 replication in vitro, or on the prevention or treatment of FHV-1 infection and its disease manifestations in cats

From: Lysine supplementation is not effective for the prevention or treatment of feline herpesvirus 1 infection in cats: a systematic review

Study N Outcome
Maggs et al. (2000) [7] N/A Lysine did not reduce the replication of FHV-1 in vitro.
Stiles et al. (2002) [13] 8 Lower mean clinical score for experimentally induced conjunctivitis during days 5–15 in a group of 4 cats receiving supplemental lysine when compared to 4 controls. +
Maggs et al. (2003) [10] 14 Supplementing lysine did not reduce the chance of developing conjunctivitis or reduce its severity.
Maggs et al. (2007) [11] 50 A lysine-rich diet did not decrease the frequency or severity of ocular or upper respiratory disease in cats housed under shelter-like conditions.
Rees et al. (2008) [12] 291 Supplementation of lysine did not reduce the number of shelter cats developing upper respiratory infections or conjunctivitis.
Drazenovich et al. (2009) [9] 123 Lysine supplementation did not lower the incidence of ocular or upper respiratory disease in shelter cats.
Cave et al. (2014) [8] N/A Lysine did not inhibit replication of feline herpesvirus 1 in vitro.
  1. N, sample size; N/A, not applicable