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Table 1 Summary of studies that investigated the effect of lysine on FHV-1 replication in vitro, or on the prevention or treatment of FHV-1 infection and its disease manifestations in cats
| Study | N | Outcome | |
|---|---|---|---|
| Maggs et al. (2000) [7] | N/A | Lysine did not reduce the replication of FHV-1 in vitro. | − |
| Stiles et al. (2002) [13] | 8 | Lower mean clinical score for experimentally induced conjunctivitis during days 5–15 in a group of 4 cats receiving supplemental lysine when compared to 4 controls. | + |
| Maggs et al. (2003) [10] | 14 | Supplementing lysine did not reduce the chance of developing conjunctivitis or reduce its severity. | − |
| Maggs et al. (2007) [11] | 50 | A lysine-rich diet did not decrease the frequency or severity of ocular or upper respiratory disease in cats housed under shelter-like conditions. | − |
| Rees et al. (2008) [12] | 291 | Supplementation of lysine did not reduce the number of shelter cats developing upper respiratory infections or conjunctivitis. | − |
| Drazenovich et al. (2009) [9] | 123 | Lysine supplementation did not lower the incidence of ocular or upper respiratory disease in shelter cats. | − |
| Cave et al. (2014) [8] | N/A | Lysine did not inhibit replication of feline herpesvirus 1 in vitro. | − |
