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Table 4 Potential candidate genes for involvement in resistance to IBV

From: The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds

Gene

Description

Fold change

GenBank

Ensembl

MX1

Interferon-induced GTP-binding protein Mx.

4–24a

NM_204609

ENSGALG00000016142

C1S

Complement component 1, s subcomponent

2a

NM_001030777

ENSGALG00000014603

IRF7

Interferon regulatory factor 7 (IRF-7).

6a

NM_205372

ENSGALG00000014297

TLR3

Toll-like receptor 3

4a

NM_001011691

ENSGALG00000013468

C1R

Complement component 1, r subcomponent

2a

XM_416518

ENSGALG00000014659

CCLi7

Chemokine ah221

8a

AY037860

ENSGALG00000002343

ISG12-2

Interferon stimulated gene 12-2

16–18a

NM_001001296

ENSGALG00000013575

IFITM3

Interferon induced transmembrane protein 3

4–5a

KC876032

ENSGALG00000004243

CD38

ADP-ribosyl cyclase 1

4b

XM_420774

ENSGALG00000014508

CD4

CD4 protein

4b

NM_204649

ENSGALG00000014477

FKBP5

FK-506 binding protein 51

2b

NM_001005431

ENSGALG00000000947

STAT3

Signal transducer and activator of transcription 3 (acute-phase response factor)

3b

NM_001030931

ENSGALG00000003267

OASL

2'-5'-oligoadenylate synthetase-like

4c

NM_205041

ENSGALG00000013723

DDT

D-dopachrome tautomerase

62–72c

NM_001030667

ENSGALG00000006350

SRI

Sorcin

65–89c

NM_001080865

ENSGALG00000008985

BLB1

MHC Class II beta 1 and 2 domains

10–22c

NM_001044694

ENSGALG00000000141

IFNAR2

Interferon alpha/beta receptor 2

2–3c

NM_204858

ENSGALG00000015938

TPD52L1

Tumor protein D53 homolog

12–14c

NM_204215

ENSGALG00000014843

BCL2L1

BCL2-like - apoptosis regulator

1.7c

NM_001025304

ENSGALG00000006211

FAIM2

Fas apoptotic inhibitory molecule 2

1.7c

XM_004950568

ENSGALG00000027555

CIAPIN1

Cytokine Induced Apoptosis Inhibitor 11

1.7c

NM_001005834

ENSGALG00000005706

HSCB

Co-chaperone protein HscB, mitochondrial precursor (Hsc20).

8–10c

XR_026662

ENSGALG00000005706

BF1

MHC class I antigen B-F minor heavy chain

13–27c

NM_001097530

ENSGALG00000000178

BF2

Major class I glycoprotein precursor

7–8c

NM_001031338

ENSGALG00000000178

SUCLG2

succinate-CoA ligase, GDP-forming, beta subunit

16–32c

NM_001006141

ENSGALG00000007652

  1. aUpregulated in response to infection in the susceptible line
  2. bHigher expression in response to infection in the resistant than in the susceptible line
  3. cInherently higher expression in the resistant line