|
Variable
|
Baseline (undiluted)
|
0.9 % NaCl (dilution 1:16)
|
0.9 % NaCl (dilution 1:8)
|
3 % HTS (dilution 1:16)
|
3 % HTS (dilution 1:8)
|
20 % mannitol (dilution 1:16)
|
20 % mannitol (dilution 1:8)
|
|---|
|
PFA-100
| | | | | | | |
|
CtPFA (s)
|
60 (51–88)
|
73 (64–83)
|
72 (68–81)
|
77 (70–90)
|
108 (84–126)*,**
|
108 (89–132)*
|
172 (124–300)*,**,***
|
|
Ex-tem
| | | | | | | |
|
CT (s)
|
35 (28–55)
|
38 (36–60)
|
44 (31–62)
|
37 (33–83)
|
40 (34–48)
|
51 (38–99)*
|
90 (46–134)*,***
|
|
CFT (s)
|
149 (131–159)
|
151 (128–184)
|
151 (123–175)
|
186 (148–206)
|
196 (176–249)*,**
|
204 (158–249)*
|
252 (222–314)*,**,***
|
|
MCF (mm)
|
59 (55–62)
|
56 (50–60)
|
55 (53–57)
|
54 (51–57)
|
50 (46–53)*,**
|
53 (51–56)
|
49 (45–50)*,**
|
|
Fib-tem
| | | | | | | |
|
CT (s)
|
38 (30–43)
|
41 (33–51)
|
38 (32–47)
|
36 (32–42)
|
36 (32–43)
|
54 (28–66)
|
48 (38–58)
|
|
MCF (mm)
|
8 (8–10)
|
7 (5–9)
|
7 (6–8)
|
7 (6–9)
|
7 (6–9)
|
7 (4–9)
|
5 (4–5)*,**,***
|
- Values are presented as median (interquartile range) *significant difference (P < 0.05) compared with baseline; **significant difference (P < 0.05) compared with 0.9 % saline at the same dilution; ***significant difference (P > 0.05) compared with 3 % HTS at the same dilution. Ct
PFA
closure time, CT clotting time, CFT clot formation time, HTS hypertonic saline, MCF maximum clot firmness
