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Table 1 Thromboelastometry and platelet function analyses in undiluted blood samples and samples diluted with 0.9 % saline, 3 % hypertonic saline, and 20 % mannitol in a ratio of 1:16 and 1:8 in 15 dogs

From: In vitro effects of 3 % hypertonic saline and 20 % mannitol on canine whole blood coagulation and platelet function

Variable Baseline (undiluted) 0.9 % NaCl (dilution 1:16) 0.9 % NaCl (dilution 1:8) 3 % HTS (dilution 1:16) 3 % HTS (dilution 1:8) 20 % mannitol (dilution 1:16) 20 % mannitol (dilution 1:8)
PFA-100        
 CtPFA (s) 60 (51–88) 73 (64–83) 72 (68–81) 77 (70–90) 108 (84–126)*,** 108 (89–132)* 172 (124–300)*,**,***
Ex-tem        
 CT (s) 35 (28–55) 38 (36–60) 44 (31–62) 37 (33–83) 40 (34–48) 51 (38–99)* 90 (46–134)*,***
 CFT (s) 149 (131–159) 151 (128–184) 151 (123–175) 186 (148–206) 196 (176–249)*,** 204 (158–249)* 252 (222–314)*,**,***
 MCF (mm) 59 (55–62) 56 (50–60) 55 (53–57) 54 (51–57) 50 (46–53)*,** 53 (51–56) 49 (45–50)*,**
Fib-tem        
 CT (s) 38 (30–43) 41 (33–51) 38 (32–47) 36 (32–42) 36 (32–43) 54 (28–66) 48 (38–58)
 MCF (mm) 8 (8–10) 7 (5–9) 7 (6–8) 7 (6–9) 7 (6–9) 7 (4–9) 5 (4–5)*,**,***
  1. Values are presented as median (interquartile range) *significant difference (P < 0.05) compared with baseline; **significant difference (P < 0.05) compared with 0.9 % saline at the same dilution; ***significant difference (P > 0.05) compared with 3 % HTS at the same dilution. Ct PFA closure time, CT clotting time, CFT clot formation time, HTS hypertonic saline, MCF maximum clot firmness