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Table 1 Signalment and immunohistochemistry summary for all subjects evaluated

From: Peroxisome proliferator activated receptor γ protein expression is asymmetrically distributed in primary lung tumor and metastatic to lung osteosarcoma samples and does not correlate with gene methylation

Dog Age (years) Sex Breed Conducting Airwayb Macrophagesb Tumorb H&E Histologic Diagnosis
C-1 14 MC Border Collie n/a (−) n/a Normal Lung
C-2 4 MC Australian Shepherd n/a (−) n/a Normal Lung
C-3 7 MC Mixed n/a (−) n/a Normal Lung
C-4 5 FS Mixed (+) (−) n/a Normal Lung
C-5 8 MC Dachshund (+) (−) n/a Normal Lung
C-6 8 MC German Shepherd n/a (−) n/a Normal Lung
C-7 5 FS Dachshund n/a (−) n/a Normal Lung
C-9 7 FS Mixed n/a (−) n/a Normal Lung
C-10 7 MC Doberman Pinscher n/a (−) n/a Normal Lung
C-15 13 MI Mixed (+) (−) n/a Normal Lung
C-17 9 FS Labrador Retriever (+) (−) n/a Normal Lung
C-18 7 FS Shih Tzu n/a (−) n/a Normal Lung
C-19 9 MC Boxer n/a (−) n/a Normal Lung
C-20 10 FI Labrador Retriever n/a (−) n/a Normal Lung
C-21 12 MC West Highland Terrier (+) (−) n/a Normal Lung
C-22 9 MC Mixed n/a (−) n/a Normal Lung
O-2 10 MC Weimaraner (+) (−) (−) Metastatic Osteosarcoma
O-3 8 MI Rottweiler (+) (+) (−) Metastatic Osteosarcoma
O-4 7 MC Golden Retriever n/a (+) (+) Metastatic Osteosarcoma
O-5 10 FS Mixed n/a (−) (+) Metastatic Osteosarcoma
O-6 5 MC Labrador Retriever a a a Metastatic Osteosarcoma
O-9 10 FS Staffordshire Terrier (+) (−) (+) Metastatic Osteosarcoma
O-10 8 MC Great Dane n/a (−) (+) Metastatic Osteosarcoma
O-11 5 MC Golden Retriever (+) (−) (+) Metastatic Osteosarcoma
O-12 10 FS Mixed (+) (+) (−) Metastatic Osteosarcoma
O-13 11 FS Mixed (+) (−) (+) Metastatic Osteosarcoma
P-1 11 MC Mixed (+) (−) (−) Large cell carcinoma
P-3 14 FS Bichon Frise (+) (+) (+) Bronchioloalveolar carcinoma
P-4 11 FS Greyhound (−) (+) (−) Adenosquamous carcinoma
P-8 9 FS Scottish Terrier (+) (−) (−) Bronchioloalveolar carcinoma
P-9 13 MC Mixed (+) (+) (−) Bronchioloalveolar carcinoma
P-10 10 MC Cocker Spaniel (+) (−) (−) Bronchioloalveolar carcinoma
P-12 10 FS Boston Terrier (+) (−) (+) Bronchial gland carcinoma
P-13 10 MC Boxer a a a Acinar Pulmonary adenocarcinoma a
P-14 12 FS Gordon Setter (+) (+) (−) Papillary adenocarcinoma
P-15 14 MC Mixed (+) (−) (+) Papillary adenocarcinoma
P-16 14 FS Welsh Corgi (+) (−) (−) Large cell carcinoma
P-17 15 MC Welsh Corgi (+) (+) (+) Solid adenocarcinoma
P-19 11 FS Mixed (+) (−) (−) Bronchioloalveolar carcinoma
  1. MC male castrated; MI male intact; FS female spayed; FI female intact; (-) Negative/None/Few/Low; (+) Positive/Mild/Moderate/High/Intense; n/a not evaluable/not present
  2. anot included in IHC analysis, italics = this diagnosis was made by necropsy pathologist, unable to confirm specific subtype, bSee materials and methods