Table 3 Risk-of-bias assessments for 20 OTP-controlled RCTs
i: Individualised/Treatment | |||||||||||||
Ref. | First author | Domain I | Domain II | Domain IIIA | Domain IIIB | Domain IV | Domain V | Domain VI (excl. fund) | No. of domains for which criteria fulfilled | Risk of bias (excl. vested interest) | Reliable evidence | ||
Y | U | N | |||||||||||
A12 | Schütte | N | N | N | N | Y | N | U | 1 | 1 | 5 | High | No |
ii: Non-individualised/Treatment | |||||||||||||
Ref. | First author | Domain I | Domain II | Domain IIIA | Domain IIIB | Domain IV | Domain V | Domain VI (excl. fund) | No. of domains for which criteria fulfilled | Risk of bias (excl. vested interest) | Reliable evidence | ||
Y | U | N | |||||||||||
A42 | Lohr | Y | U | N | Y | Y | N | N | 3 | 1 | 3 | High | No |
A14 | Coelho | U | U | N | U | Y | Y | N | 2 | 3 | 2 | High | No |
A41 | Catto | U | U | N | U | U | N | U | 0 | 5 | 2 | High | No |
A19 | Silva | U | U | N | U | U | N | U | 0 | 5 | 2 | High | No |
A40 | Lotfollahzadeh | U | U | N | Y | U | N | Y | 2 | 3 | 2 | High | No |
A21 | Zacharias | U | U | N | U | U | Y | U | 1 | 5 | 1 | High | No |
A15 | Faulstich | Y | U | N | Y | Y | Y | Y | 5 | 1 | 1 | High | No |
A16 | Klocke | Y | U | N | U | Y | Y | Y | 4 | 2 | 1 | High | No |
A20 | Varshney | U | U | U | U | U | Y | N | 1 | 5 | 1 | High | No |
A39 | Braun | Y | U | N | Y | Y | Y | N | 4 | 1 | 2 | High | No |
A13 | Beceriklisoy | U | U | U | U | U | Y | N | 1 | 5 | 1 | High | No |
A18 | Sandoval | U | U | U | U | U | N | U | 0 | 6 | 1 | High | No |
A17 | Rocha | N | N | U | U | Y | Y | U | 2 | 3 | 2 | High | No |
iii: Non-individualised/Prophylaxis | |||||||||||||
Ref. | First author | Domain I | Domain II | Domain IIIA | Domain IIIB | Domain IV | Domain V | Domain VI (excl. fund) | No. of domains for which criteria fulfilled | Risk of bias (excl. vested interest) | Reliable evidence | ||
Y | U | N | |||||||||||
A34 | Signoretti | U | U | U | U | U | Y | Y | 2 | 5 | 0 | Uncertain | No |
A36 | Soto | U | U | U | U | Y | Y | U | 2 | 5 | 0 | Uncertain | No |
A31 | Reis 2006 | U | U | U | U | U | Y | Y | 2 | 5 | 0 | Uncertain | No |
A32 | Reis 2008 | U | U | U | U | U | Y | Y | 2 | 5 | 0 | Uncertain | No |
A35 | Sommer | U | U | N | U | Y | Y | U | 2 | 4 | 1 | High | No |
A38 | Williamson | U | U | N | U | U | N | U | 0 | 5 | 2 | High | No |