Fig. 5
From: Phylodynamic analysis of the canine distemper virus hemagglutinin gene
Site-specific variation among global canine distemper virus H sequences. a Detection of site-specific selection. Normalized dN-dS values were plotted for each codon site by using the SLAC method on the DataMonkey website. b Secondary structure guide for Measles virus (MeV) H protein (PDB ID codes 2ZP8). c Epistatic interactions among CDV H protein residues. Each square node represents the position of a residue in a CDV H amino acid sequence identified in at least one interaction. The analysis detected edges with marginal posterior probabilities (PPs) exceeding a default cutoff value of 0.5. Data are shown as PP(→)/PP(↔)/PP(←). The arrows indicate the directions of interactions. d The multiple epistatic sites detected in this study are labeled in the simplified secondary structure. Each amino acid residue and its coordinate structure are also denoted