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Table 2 The pharmacokinetics parameters of cefquinome following multiple-dose in the E.coli-infected piglets

From: Response of a clinical Escherichia coli strain to repeated cefquinome exposure in a piglet tissue-cage model

Cefquinome dose

AUC0–12

Cmax

(mg/kg of body weight)

(μg · h/mL)

(μg/mL)

0.2

1.346 ± 0.046

0.135 ± 0.004

0.4

1.553 ± 0.066

0.170 ± 0.007

0.6

2.802 ± 0.044

0.286 ± 0.001

0.8

3.693 ± 0.088

0.396 ± 0.008

1

4.230 ± 0.013

0.448 ± 0.003

2

11.157 ± 0.048

1.175 ± 0.024

4

20.730 ± 0.0640

2.069 ± 0.070

  1. The AUC0–12 and Cmax were the mean values of multiple-dose (six times). AUC0–12, area under the concentration-time curve from 0 to 12 h after every administration, was determined by use of the trapezoidal rule; the Cmax was directly from the concentration-time curve of every administration. The values shown are means ± standard deviations
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BMC Veterinary Research

ISSN: 1746-6148

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