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Table 3 Concentrations of LBP, Hp, Lf, and CRP in the BALF supernatant of healthy calves and of calves with an experimentally induced respiratory Chlamydia psittaci infection

From: Acute phase proteins as local biomarkers of respiratory infection in calves

  LBP [ng × mL−1] Hp [ng × mL−1] Lf [μg × mL−1] CRP [ng × mL−1]
Healthy controls 9.5 (1.7–23.6) 107.3 (3.0–347.0) 0.96 (0.4–2.8) 0.104 (0.0–0.3)
Infected 4 dpi 61.5 (12.4–172.9)*,a 12.3 (1.6–12554.8)a 0.38 (0.1–3.6)a 0.399 (0.0–7.9)
Infected 9 dpi 15.5 (5.5–35.3)b 11.6 (1.3–2120.9)a 0.26 (0.1–0.8)* 0.212 (0.0–0.8)
Infected 14 dpi 12.0 (2.5–24.1)b 0.7 (0.0–3.9)*, b 0.17 (0.1–1.0)*,b 0.523 (0.0–3.0)
  1. Values are given as median (minimum-maximum). Concentrations for healthy controls (n = 6) are only given for the first sampling point. Asterisks indicate significant differences compared to healthy controls (Mann–Whitney-U test with Holm adjustment, P < 0.05). Different small letters (a,b) indicate significant differences between different time points in infected animals (Wilcoxon signed rank test with Holm adjustment, P < 0.05). Infected: animals inoculated with C. psittaci (n = 13); dpi days after inoculation; BSA bovine serum albumin; LBP lipopolysaccharide binding protein; Hp haptoglobin; Lf lactoferrin; CRP C reactive protein