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Table 3 Effect of four different intranasal treatments on the serum IgG immune response (OD values ± s.d) values in Friesian calves

From: Comparing the immune response to a novel intranasal nanoparticle PLGA vaccine and a commercial BPI3V vaccine in dairy calves

Treatments

Pre I

1 week PI

2 weeks PI

3 weeks PI

4 weeks PI

1 week PB

2 weeks PB

3 weeks PB

4 weeks PB

Half euthanised

5 days PE

12 days PE

2 weeks PE

3 weeks PE

T × S

 

Day 0

Day 7

Day 14

Day 21

Day 28

Day 42

Day 49

Day 56

Day 63

Day 71

Day 76

Day 83

Day 85

Day 92

 

Commercial vaccine

0.50a ± 0.39

0.59a ± 0.67

1.01b ± 0.43

0.92b ± 0.45

0.82ab ± 0.45

0.76a ± 0.45

0.94b ± 0.39

1.04b ± 0.42

1.39c ± 0.46

1.47c ± 0.57

1.28c ± 0.48

1.25bc ± 0.56

1.34c ± 0.63

1.25bc ± 0.66

**

Empty NPs

0.47a ± 0.14

0.49a ± 0.19

0.45a ± 0.17

0.45a ± 0.18

0.39a ± 0.15

0.35a ± 0.13

0.40a ± 0.15

0.46a ± 0.21

0.68a ± 0.2

0.66ab ± 0.2

0.72b ± 0.27

0.54ab ± 0.23

0.55ab ± 0.25

0.51ab ± 0.18

NS

BPI3V

0.46a ± 0.16

0.69a ± 0.26

0.72a ± 0.31

0.65a ± 0.23

0.64a ± 0.24

0.69a ± 0.22

0.81a ± 0.26

1.10b ± 0.52

1.10b ± 0.46

1.22bc ± 0.27

1.03b ± 0.33

1.43c ± 0.27

1.14b ± 0.52

1.03b ± 0.47

**

PLGA-BPI3V-NPs

0.43a ± 0.12

0.78b ± 0.44

0.75b ± 0.45

0.69b ± 0.4

0.62b ± 0.33

0.72b ± 0.47

0.77b ± 0.47

0.96bc ± 0.44

0.92bc ± 0.38

1.06c ± 0.42

1.14c ± 0.36

1.11c ± 0.43

1.04c ± 0.46

1.13c ± 0.54

**

  1. Pre I Pre immunisation sampling, PI Post immunisation, PB Post booster, PE Post euthanasia, T × S treatment × sampling time interaction. Levels of significance: NS = P > 0.05, ** = P < 0.05, *** = P < 0.001. a,b,c, Within a row, means without a common superscript letter differ (P ≤ 0.05)