Treatments | Pre I | 1 week PI | 2 weeks PI | 3 weeks PI | 4 weeks PI | 1 week PB | 2 weeks PB | 3 weeks PB | 4 weeks PB | Half euthanised | 5 days PE | 12 days PE | 2 weeks PE | 3 weeks PE | T × S |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Day 0 | Day 7 | Day 14 | Day 21 | Day 28 | Day 42 | Day 49 | Day 56 | Day 63 | Day 71 | Day 76 | Day 83 | Day 85 | Day 92 |  |
Commercial vaccine | 0.50a ± 0.39 | 0.59a ± 0.67 | 1.01b ± 0.43 | 0.92b ± 0.45 | 0.82ab ± 0.45 | 0.76a ± 0.45 | 0.94b ± 0.39 | 1.04b ± 0.42 | 1.39c ± 0.46 | 1.47c ± 0.57 | 1.28c ± 0.48 | 1.25bc ± 0.56 | 1.34c ± 0.63 | 1.25bc ± 0.66 | ** |
Empty NPs | 0.47a ± 0.14 | 0.49a ± 0.19 | 0.45a ± 0.17 | 0.45a ± 0.18 | 0.39a ± 0.15 | 0.35a ± 0.13 | 0.40a ± 0.15 | 0.46a ± 0.21 | 0.68a ± 0.2 | 0.66ab ± 0.2 | 0.72b ± 0.27 | 0.54ab ± 0.23 | 0.55ab ± 0.25 | 0.51ab ± 0.18 | NS |
BPI3V | 0.46a ± 0.16 | 0.69a ± 0.26 | 0.72a ± 0.31 | 0.65a ± 0.23 | 0.64a ± 0.24 | 0.69a ± 0.22 | 0.81a ± 0.26 | 1.10b ± 0.52 | 1.10b ± 0.46 | 1.22bc ± 0.27 | 1.03b ± 0.33 | 1.43c ± 0.27 | 1.14b ± 0.52 | 1.03b ± 0.47 | ** |
PLGA-BPI3V-NPs | 0.43a ± 0.12 | 0.78b ± 0.44 | 0.75b ± 0.45 | 0.69b ± 0.4 | 0.62b ± 0.33 | 0.72b ± 0.47 | 0.77b ± 0.47 | 0.96bc ± 0.44 | 0.92bc ± 0.38 | 1.06c ± 0.42 | 1.14c ± 0.36 | 1.11c ± 0.43 | 1.04c ± 0.46 | 1.13c ± 0.54 | ** |