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Table 2 Effect of four different intranasal treatments on the nasal mucus IgA immune response (OD values ± s.d) in Friesian calves

From: Comparing the immune response to a novel intranasal nanoparticle PLGA vaccine and a commercial BPI3V vaccine in dairy calves

Treatments

Pre I

1 week PI

2 weeks PI

3 weeks PI

4 weeks PI

1 week PB

2 weeks PB

3 weeks PB

4 weeks PB

Half euthanised

5 days PE

2 weeks PE

3 weeks PE

T × S

 

Day 0

Day 7

Day 14

Day 21

Day 28

Day 42

Day 49

Day 56

Day 63

Day 71

Day 76

Day 85

Day 92

 

Commercial vaccine

1.28a ± 0.24

1.71a ± 0.79

1.43a ± 0.78

1.72a ± 0.84

1.38a ± 0.54

1.49a ± 0.51

2.33b ± 1.13

1.62a ± 0.71

2.03b ± 0.48

1.7a ± 0.67

1.49a ± 0.52

1.55a ± 0.89

1.71a ± 1

NS

Empty NPs

1.32a ± 0.31

1.59a ± 0.64

1.45a ± 0.45

1.64a ± 0.7

1.22a ± 0.57

1.50a ± 0.57

1.70a ± 0.9

1.32a ± 0.54

1.40a ± 0.77

1.71a ± 0.77

1.21a ± 0.86

0.98b ± 0.61

1.18ab ± 0.78

NS

BPI3V

1.09a ± 0.21

1.96b ± 0.58

1.91b ± 0.72

2.34b ± 0.62

1.92b ± 0.62

2.24b ± 0.61

2.24b ± 0.92

2.21b ± 0.44

2.22b ± 0.76

2.18b ± 0.6

1.36ab ± 0.4

1.49b ± 0.93

1.18a ± 0.87

NS

PLGA-BPI3V-NPs

1.10a ± 0.3

1.73b ± 0.4

1.34ab ± 0.3

1.68b ± 0.44

1.77b ± 0.44

1.85b ± 0.5

2.96c ± 0.66

2.63c ± 0.44

2.94c ± 0.71

3.10c ± 1.28

3.10c ± 0.73

3.15c ± 0.72

3.15c ± 0.71

**

  1. Pre I Pre immunisation sampling, PI Post immunisation, PB Post booster, PE Post euthanasia, T × S treatment × sampling time interaction. Levels of significance: NS = P > 0.05, ** = P < 0.05, *** = P < 0.001. a,b,c, Within a row, means without a common superscript letter differ (P ≤ 0.05)