Treatments | Pre I | 1 week PI | 2 weeks PI | 3 weeks PI | 4 weeks PI | 1 week PB | 2 weeks PB | 3 weeks PB | 4 weeks PB | Half euthanised | 5 days PE | 2 weeks PE | 3 weeks PE | T × S |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Day 0 | Day 7 | Day 14 | Day 21 | Day 28 | Day 42 | Day 49 | Day 56 | Day 63 | Day 71 | Day 76 | Day 85 | Day 92 |  |
Commercial vaccine | 1.28a ± 0.24 | 1.71a ± 0.79 | 1.43a ± 0.78 | 1.72a ± 0.84 | 1.38a ± 0.54 | 1.49a ± 0.51 | 2.33b ± 1.13 | 1.62a ± 0.71 | 2.03b ± 0.48 | 1.7a ± 0.67 | 1.49a ± 0.52 | 1.55a ± 0.89 | 1.71a ± 1 | NS |
Empty NPs | 1.32a ± 0.31 | 1.59a ± 0.64 | 1.45a ± 0.45 | 1.64a ± 0.7 | 1.22a ± 0.57 | 1.50a ± 0.57 | 1.70a ± 0.9 | 1.32a ± 0.54 | 1.40a ± 0.77 | 1.71a ± 0.77 | 1.21a ± 0.86 | 0.98b ± 0.61 | 1.18ab ± 0.78 | NS |
BPI3V | 1.09a ± 0.21 | 1.96b ± 0.58 | 1.91b ± 0.72 | 2.34b ± 0.62 | 1.92b ± 0.62 | 2.24b ± 0.61 | 2.24b ± 0.92 | 2.21b ± 0.44 | 2.22b ± 0.76 | 2.18b ± 0.6 | 1.36ab ± 0.4 | 1.49b ± 0.93 | 1.18a ± 0.87 | NS |
PLGA-BPI3V-NPs | 1.10a ± 0.3 | 1.73b ± 0.4 | 1.34ab ± 0.3 | 1.68b ± 0.44 | 1.77b ± 0.44 | 1.85b ± 0.5 | 2.96c ± 0.66 | 2.63c ± 0.44 | 2.94c ± 0.71 | 3.10c ± 1.28 | 3.10c ± 0.73 | 3.15c ± 0.72 | 3.15c ± 0.71 | ** |