Table 5 Reasons why it may be appropriate to perform volumetric studies on hippocampus or other potentially epileptogenic areas
Rationale for volumetric analysis | |
|---|---|
➢ To establish normative date | |
● Breed and size variations | |
● Age | |
● Gender | |
● Within subject functional and anatomical asymmetry [75] | |
➢ To provide a baseline | |
● At initial diagnosis and for serial comparison, for example, if develops drug-resistant epilepsy | |
➢ To identify patients with poor prognosis / less likely to respond to treatment | |
● Volume compared to normative data | |
● Within subject asymmetry in volume | |
➢ Improving cohort selection for entry into clinical trials evaluating | |
● Antiepileptic drugs | |
● Neuro-protective agents that may modulate the consequences of epilepsy on cognition and behaviour [76] | |
● Novel treatment modalities |