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Table 3 Micro-CT results

From: Effects of diacerein on cartilage and subchondral bone in early stages of osteoarthritis in a rabbit model

  CTRL OA CTRL + DC OA + DC
  mean ± std.dev mean ± std.dev mean ± std.dev mean ± std.dev
Subchondral bone microstructure
BV/TV (%) 48.46 ± 7.74c 49.37 ± 4.38 56.34 ± 2.96a 51.92 ± 4.99
Tb.Th (μm) 265.21 ± 32.62 288.75 ± 60.43 283.20 ± 34.22 281.18 ± 56.18
Tb.Sp (μm) 467.24 ± 122.46c 423.12 ± 66.21 354.74 ± 36.25a 433.27 ± 54.03
Tb.N (mm−1) 1.83 ± 0.20 1.76 ± 0.29 2.01 ± 0.23 1.89 ± 0.30
Tb.Pf (mm−1) −3.27 ± 1.49 −3.24 ± 0.51 −4.16 ± 1.54 −4.01 ± 1.15
SMI −0.66 ± 0.47 −0.72 ± 0.39 −1.07 ± 0.48 −0.96 ± 0.60
DA 0.71 ± 0.06c,d 0.69 ± 0.06c,d 0.57 ± 0.09a,b 0.57 ± 0.06a,b
Volumetric subchondral bone mineral density
vBMD (mg/cm3) 505.90 ± 98.53 512.78 ± 52.52c 608.36 ± 24.43b 548.69 ± 58.95
Cartilage morphology
nCg.Th (μm) 309.06 ± 62.99b 494.80 ± 169.59a,c,d 269.01 ± 39.93b 359.75 ± 48.62b
nCg.V (mm3) 3.37 ± 0.78b 5.69 ± 2.72a,c 2.81 ± 0.52b 3.71 ± 0.50
  1. Mean values ± standard deviation of the micro-CT parameters obtained for all experimental groups. All variables showed a normal distribution, and only vBMD showed no homogeneity of variances. Statistical significance p < 0.05: a vs. CTRL; b vs. OA; c vs. CTRL + DC; d vs. OA + DC