| |
CTRL
|
OA
|
CTRL + DC
|
OA + DC
|
|---|
| |
mean ± std.dev
|
mean ± std.dev
|
mean ± std.dev
|
mean ± std.dev
|
|---|
|
Subchondral bone microstructure
|
|
BV/TV (%)
|
48.46 ± 7.74c
|
49.37 ± 4.38
|
56.34 ± 2.96a
|
51.92 ± 4.99
|
|
Tb.Th (μm)
|
265.21 ± 32.62
|
288.75 ± 60.43
|
283.20 ± 34.22
|
281.18 ± 56.18
|
|
Tb.Sp (μm)
|
467.24 ± 122.46c
|
423.12 ± 66.21
|
354.74 ± 36.25a
|
433.27 ± 54.03
|
|
Tb.N (mm−1)
|
1.83 ± 0.20
|
1.76 ± 0.29
|
2.01 ± 0.23
|
1.89 ± 0.30
|
|
Tb.Pf (mm−1)
|
−3.27 ± 1.49
|
−3.24 ± 0.51
|
−4.16 ± 1.54
|
−4.01 ± 1.15
|
|
SMI
|
−0.66 ± 0.47
|
−0.72 ± 0.39
|
−1.07 ± 0.48
|
−0.96 ± 0.60
|
|
DA
|
0.71 ± 0.06c,d
|
0.69 ± 0.06c,d
|
0.57 ± 0.09a,b
|
0.57 ± 0.06a,b
|
|
Volumetric subchondral bone mineral density
|
|
vBMD (mg/cm3)
|
505.90 ± 98.53
|
512.78 ± 52.52c
|
608.36 ± 24.43b
|
548.69 ± 58.95
|
|
Cartilage morphology
|
|
nCg.Th (μm)
|
309.06 ± 62.99b
|
494.80 ± 169.59a,c,d
|
269.01 ± 39.93b
|
359.75 ± 48.62b
|
|
nCg.V (mm3)
|
3.37 ± 0.78b
|
5.69 ± 2.72a,c
|
2.81 ± 0.52b
|
3.71 ± 0.50
|
- Mean values ± standard deviation of the micro-CT parameters obtained for all experimental groups. All variables showed a normal distribution, and only vBMD showed no homogeneity of variances. Statistical significance p < 0.05: a vs. CTRL; b vs. OA; c vs. CTRL + DC; d vs. OA + DC
