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Table 2 Qualitative histological results

From: Effects of diacerein on cartilage and subchondral bone in early stages of osteoarthritis in a rabbit model

  CTRL OA CTRL + DC OA + DC
  median (25, 75) median (25, 75) median (25, 75) median (25, 75)
μ ± std.dev μ ± std.dev μ ± std.dev μ ± std.dev
Microscopic grading of cartilage alterations
Severity of cartilage pathology 0 (0, 0.75) 1 (0.25, 1.75) 0 (0, 0.5) 0 (0, 1)
0.29 ± 0.49 1 ± 0.82 0.25 ± 0.46 0.5 ± 0.76
Severity of chondrocyte pathology 0 (0, 1) 1 (0.25, 2.5) 1 (0, 1) 1 (1, 3)
0.57 ± 0.79 1.21 ± 1.15 0.56 ± 0.5 1.81 ± 1.19
Severity of proteoglycan pathology 0 (0, 0) 1 (0, 2) 0 (0, 3) 1.5 (0, 3)
0.33 ± 0.82 1.29 ± 1.5 1.25 ± 1.83 1.56 ± 1.68
Tidemark integrity 1 (0.5, 2) 0 (0, 2) 1 (1, 1) 0.5 (0, 2)
1.13 ± 0.83 0.67 ± 1.03 1 ± 0.53 0.88 ± 0.99
Microscopic grading of synovial changes
Lining cells characteristics 0 (0, 0)b,c,d 1 (1, 1)a,c,d 0 (0, 1)a,b 0 (0, 0.75)a,b
0 ± 0 1 ± 0.63 0.4 ± 0.55 0.29 ± 0.49
Presence of hyperplasia 0 (0, 0)b,c,d 1 (1, 2)a,c,d 0 (0, 0.25)a,b,d 1 (0.25, 1)a,b,c
0.13 ± 0.35 1.17 ± 0.75 0.2 ± 0.45 0.86 ± 0.69
Cell infiltration characteristics 0 (0, 0) 1 (0, 1) 0 (0, 1) 0 (0, 0.75)
0 ± 0 0.67 ± 0.52 0.4 ± 0.55 0.29 ± 0.49
  1. Comparison between experimental groups with different scores for microscopic grading of cartilage and synovial alterations, obtained from decalcified samples. All parameters showed a non-normal distribution. Statistical significance p < 0.05: a vs. CTRL; b vs. OA; c vs. CTRL + DC; d vs. OA + DC