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Table 2 Qualitative histological results

From: Effects of diacerein on cartilage and subchondral bone in early stages of osteoarthritis in a rabbit model

 

CTRL

OA

CTRL + DC

OA + DC

 

median (25, 75)

median (25, 75)

median (25, 75)

median (25, 75)

μ ± std.dev

μ ± std.dev

μ ± std.dev

μ ± std.dev

Microscopic grading of cartilage alterations

Severity of cartilage pathology

0 (0, 0.75)

1 (0.25, 1.75)

0 (0, 0.5)

0 (0, 1)

0.29 ± 0.49

1 ± 0.82

0.25 ± 0.46

0.5 ± 0.76

Severity of chondrocyte pathology

0 (0, 1)

1 (0.25, 2.5)

1 (0, 1)

1 (1, 3)

0.57 ± 0.79

1.21 ± 1.15

0.56 ± 0.5

1.81 ± 1.19

Severity of proteoglycan pathology

0 (0, 0)

1 (0, 2)

0 (0, 3)

1.5 (0, 3)

0.33 ± 0.82

1.29 ± 1.5

1.25 ± 1.83

1.56 ± 1.68

Tidemark integrity

1 (0.5, 2)

0 (0, 2)

1 (1, 1)

0.5 (0, 2)

1.13 ± 0.83

0.67 ± 1.03

1 ± 0.53

0.88 ± 0.99

Microscopic grading of synovial changes

Lining cells characteristics

0 (0, 0)b,c,d

1 (1, 1)a,c,d

0 (0, 1)a,b

0 (0, 0.75)a,b

0 ± 0

1 ± 0.63

0.4 ± 0.55

0.29 ± 0.49

Presence of hyperplasia

0 (0, 0)b,c,d

1 (1, 2)a,c,d

0 (0, 0.25)a,b,d

1 (0.25, 1)a,b,c

0.13 ± 0.35

1.17 ± 0.75

0.2 ± 0.45

0.86 ± 0.69

Cell infiltration characteristics

0 (0, 0)

1 (0, 1)

0 (0, 1)

0 (0, 0.75)

0 ± 0

0.67 ± 0.52

0.4 ± 0.55

0.29 ± 0.49

  1. Comparison between experimental groups with different scores for microscopic grading of cartilage and synovial alterations, obtained from decalcified samples. All parameters showed a non-normal distribution. Statistical significance p < 0.05: a vs. CTRL; b vs. OA; c vs. CTRL + DC; d vs. OA + DC