Fig. 3

Leucocyte counts. Leucocyte quantities in peripheral blood measured by automated haematology systems are plotted as differences to individual time-of-day matched baselines (BL) for t0, t12 and t24. Datasets are marked as (group)-(hours post-treatment) at the X-axes. Horizontal bars represent mean and SD. Grey asterisks (*) represent significant differences from baseline in the respective dataset. Asterisks (*) with brackets (┌ ┌) represent significantly different comparisons. a Increases of WBC induced by B and D at t24 were significantly higher than in A. b The increase in neutrophils was significantly different from baseline in B at t24. Group A showed significantly less treatment effects than B, C and D at t24. c In comparison to individual baselines, lymphocyte numbers decreased significantly after treatment B at t12 and t24, and at t24 in C and D