Skip to main content

Table 6 Comparative mean (±SD) kinetic parameters of (−) ABZ-SO and (+) ABZ-SO in goats and sheep following subcutaneous administrations at dose rates of 5, 10 and 15 mg/kg (n = 8)

From: Comparative pharmacokinetics and bioavailability of albendazole sulfoxide in sheep and goats, and dose-dependent plasma disposition in goats

Parameters

Sheep

Goats

5 mg/kg

5 mg/kg

10 mg/kg

15 mg/kg

(−) ABZ-SO

(+) ABZ-SO

(−) ABZ-SO

(+) ABZ-SO

(−) ABZ-SO

(+) ABZ-SO

(−) ABZ-SO

(+) ABZ-SO

T1/2λz (h)

6.23 ± 1.71

9.74 ± 6.40

4.56 ± 1.55

7.95 ± 4.59

4.79 ± 1.57

7.36 ± 3.51

4.85 ± 1.93*

7.57 ± 3.29

Tmax (h)

7.43 ± 1.51

9.14 ± 1.95

8.00 ± 0.00

8.80 ± 1.79

7.43 ± 1.51

10.29 ± 3.15

8.00 ± 0.00

8.00 ± 2.14

Cmax (μg/mL)

0.95 ± 0.22

1.12 ± 0.21

0.92 ± 0.24

1.03 ± 0.20

1.74 ± 0.45

1.75 ± 0.46

3.05 ± 0.33

3.38 ± 0.84

AUClast (μg.h/mL)

15.27 ± 2.67*

28.22 ± 10.36

12.48 ± 4.14*

21.99 ± 6.96

25.41 ± 4.93*

40.00 ± 9.03

44.12 ± 6.84*

74.73 ± 16.43

MRTlast (h)

12.20 ± 1.94*

19.45 ± 7.91

10.20 ± 1.60

16.15 ± 6.43

10.82 ± 1.26*

16.74 ± 3.27

10.34 ± 1.14*

16.49 ± 3.32

  1. T 1/2λz terminal half-life; T max time to reach peak plasma concentration; C max peak plasma concentration; AUC last area under the (zero moment) curve from time 0 to the last detectable concentration; MRT last mean residence time
  2. *Differences between the enantiomers in the same animals and dose rates (P < 0.05)
Back to article page

BMC Veterinary Research

ISSN: 1746-6148

Contact us