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Table 4 Comparative mean (±SD) kinetic parameters of ABZ-SO in goats and sheep at a dose rate of 5 mg/kg and at increased dose rates (10 and 15 mg/kg) in goats following subcutaneous administrations (n = 8)

From: Comparative pharmacokinetics and bioavailability of albendazole sulfoxide in sheep and goats, and dose-dependent plasma disposition in goats

Parameters

Sheep

Goats

5 mg/kg

5 mg/kg

10 mg/kg

15 mg/kg

T1/2λz (h)

4.99 ± 1.12*

2.44 ± 0.37b

4.62 ± 1.51

5.79 ± 1.57

Tmax (h)

8.50 ± 1.41

7.43 ± 1.51

8.00 ± 2.31

7.50 ± 1.41

Cmax (μg/mL)

2.05 ± 0.37

1.98 ± 0.37b

3.40 ± 0.84c

6.30 ± 0.81

Tlast (h)

38.00 ± 8.28*

28.57 ± 4.28

36.57 ± 7.81

35.00 ± 8.49

AUClast (μg.h/mL)

38.35 ± 9.81*

29.76 ± 6.52b

62.19 ± 13.61c

112.66 ± 17.16

MAT (h)

5.56 ± 2.07

4.53 ± 2.23b

7.07 ± 1.49

7.10 ± 1.30

MRTlast (h)

13.00 ± 1.54*

10.34 ± 1.85

12.88 ± 1.19

12.50 ± 1.70

Cmax (μg/mL) (Normalized)a

2.05 ± 0.37

1.98 ± 0.37

1.70 ± 0.42

2.10 ± 0.27

AUC (μg.h/mL) (Normalized)a

38.35 ± 9.81

29.76 ± 6.52

31.09 ± 6.30

37.55 ± 5.72

F (%)

97.9*

82.0b

91.18c

110.01

  1. T 1/2λz terminal half-life; T max time to reach peak plasma concentration; C max peak plasma concentration; T last time to last detectable plasma concentration; AUC last area under the (zero moment) curve from time 0 to the last detectable concentration; MRT last mean residence time; MAT mean absorption time; F bioavailability
  2. *The parameters in sheep are significantly different from those in goats (*P < 0.05)
  3. aAUC and Cmax values were dose-normalized dividing the observed value by 2 (10 mg/kg) or 3 (15 mg/kg)
  4. bThe parameters in goats observed after a dose of 5 mg/kg are significantly different from those in goats observed after doses of 10 and 15 mg/kg (&P < 0.05)
  5. cThe parameters in goats observed after a dose of 10 mg/kg are significantly different from those in goats observed after a dose of 15 mg/kg (&P < 0.05)